Mechanism of Action
depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. Paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple…
Microtubule Inhibitor
Clinical Trials (5)
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gastric and Gastroesophageal Junction Adenocarcinoma
Chiauranib Plus PD-1 Inhibitor, Albumin-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis
Neoadjuvant Aitua (PD-1/CTLA-4 Bispecific) Plus Nab-Paclitaxel and Carboplatin for Advanced High-Grade Serous Ovarian Cancer
Loss of Exclusivity
Patent Records (5)
| Patent # | Expiry | Type | Use Code |
|---|---|---|---|
| 8268348 | Feb 21, 2026Expired | U-1290 | |
| 9101543 | Feb 21, 2026Expired | U-1434 | |
| 7758891 | Feb 21, 2026Expired | U-1434 | |
| 8034375 | Aug 13, 2026 | U-1290 | |
| 9101543*PED | Aug 21, 2026 | — |