NDAINTRAVENOUSSOLUTION
Approved
Dec 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
3/8 — Basic
ABLAVAR (gadofosveset trisodium) by Lantheus Medical Imaging is injection, gadofosveset binds reversibly to endogenous serum albumin resulting in longer vascular residence time than non-protein binding contrast agents. First approved in 2008.
Drug data last refreshed 22h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ABLAVAR (gadofosveset trisodium) is an intravenous gadolinium-based contrast agent for magnetic resonance angiography (MRA) imaging. It binds reversibly to serum albumin, extending vascular residence time and enhancing MR signal intensity compared to non-protein-binding agents. The mechanism enables improved visualization of blood vessels during diagnostic imaging procedures.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100), signaling a contracting commercial footprint and likely team consolidation.
Mechanism of Action
injection, gadofosveset binds reversibly to endogenous serum albumin resulting in longer vascular residence time than non-protein binding contrast agents. The binding to serum albumin also increases the magnetic resonance relaxivity of gadofosveset and decreases the relaxation time (T1) of water…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
Dose-varied Evaluation of Ablavar-enhanced MR Angiography of the Central Veins of the Chest in Healthy Participants
Started Aug 2011
30 enrolled
Healthy
Pulmonary MR Angiography and Lower Extremity MR Venous Imaging Using Gadofosveset (Ablavar)
Started Jul 2011
15 enrolled
Pulmonary Embolism
Career Relevance
Career opportunities on ABLAVAR are limited and declining given its LOE-approaching status and zero linked job openings. Roles available typically focus on defensive maintenance, pricing strategy, and managed-care negotiations rather than growth-oriented functions.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.