SR. RESEARCH ASSOCIATE/ASSOCIATE SCIENTIST, NONCLINICAL DEVELOPMENT

RESEARCH ASSOCIATE/ ASSOCIATE SCIENTIST, NONCLINICAL DEVELOPMENT

Key responsibilities:

• Coordinate and execute in vivo and ex vivo nonclinical studies to evaluate Adicet’s immune-cell and gene-therapy platforms, including efficacy, pharmacokinetic/pharmacodynamic, and safety assessments in relevant murine oncology and immunology models.
• Contribute to study design, experimental planning, timeline development, and data-driven decision-making to support program advancement.
• Collaborate and communicate effectively with cross-functional teams and external contract research organizations to coordinate study execution, troubleshoot technical challenges, and ensure study endpoints align with program objectives
• Perform necropsies and process tissues for downstream analyses, including flow cytometry, qPCR/ddPCR, and ELISA, to characterize pharmacologic activity and elucidate mechanisms of action.
• Maintain accurate, complete, and well-organized experimental records in accordance with internal documentation and quality standards.

Qualifications:

• Bachelor’s degree in biological sciences or a related field with 5+ years of relevant R&D experience, or a Master’s degree with 3+ years of experience, preferably in immuno-oncology, within an industry setting.
• Significant experience designing, executing, analyzing, and interpreting in vivo studies using murine xenograft disease models and/or humanized immunology models.
• Demonstrated proficiency administering therapeutic agents and establishing xenograft models through intravenous, intraperitoneal, and subcutaneous routes in mice.
• Strong technical proficiency in blood collection, including submandibular and tail-vein sampling, as well as tissue necropsy and sample processing for flow-cytometry applications.
• Experience with aseptic mammalian cell culture, including the maintenance and preparation of human cancer cell lines for nonclinical in vivo studies.
• Hands-on experience with in vivo bioluminescence and/or fluorescence imaging, including image acquisition and data analysis using IVIS platforms.
• Experience with laboratory techniques such as flow cytometry, ELISA, qPCR/ddPCR, and cytokine bead-based assays is preferred.
• Excellent organizational, communication, data-analysis, and technical-documentation skills.
• Demonstrated ability to work independently, troubleshoot scientific and technical challenges, and contribute innovative solutions.
• Ability to manage multiple priorities and thrive in a fast-paced, collaborative, and supportive research environment.

Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.

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