Sr. Director, ADC Drug-Linker Synthetic Process Development

<p style="text-align:left">At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.</p><p style="text-align:inherit"></p><div><p><b>Overview:</b></p><p><span>At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.</span></p><p><span> </span></p><p>The current opportunity is within the Bioproduct Research and Development (BR&amp;D) organization, which is a multidisciplinary organization focused on the development and commercialization of biologic therapeutics such as monoclonal antibodies and bioconjugates.  Due to a strategic commitment to the growth of novel modalities such as Antibody-Drug Conjugates (ADCs) and an exciting pipeline of investigational medicines within the Lilly portfolio, we are seeking outstanding candidates to work at this exciting small molecule – biologics interface, focusing on small-molecule drug-linker synthetic <span><span>chemistry.</span><span> The successful candidate will </span><span>interface closely with</span><span> the </span><span>biologics</span><span> development in BR&amp;D and with the Synthetic Molecule Design and Development organization (SMDD) at Lilly.</span><span> </span></span><span> </span></p></div><div><p></p><p><b><span>Position </span><span>Responsibilities: </span></b><span> </span></p><p><span><span>To meet the needs of Lilly’s expanding and diverse portfolio of ADCs, w</span><span>e are </span><span>seeking</span><span> a highly experienced and strategic Senior Director to lead our </span><span>p</span><span>ayload </span><span>l</span><span>inker development efforts within the Antibody-Drug Conjugate (ADC) team. This role will focus on the design, optimization, and scaling of payload linker chemistry critical to </span><span>the </span><span>manufactur</span><span>ing </span><span>of next-generation ADC therapeutics.</span><span> </span><span>The successful candidate will also </span><span>exhibit</span><span> a strong commitment </span><span>in</span><span> employee development and thrive in a </span><span>collaborative and</span><span> fast-paced work environment.</span> </span></p><ul><li><p><span><span>Lead and oversee CMC process development activities for </span><span>novel </span><span>payloads and drug-linkers within ADC programs, ensuring alignment with overall program goals.</span> </span></p></li><li><p><span><span>Collaborate closely with Discovery teams to ensure manufacturability and </span><span>facilitate</span><span> smooth transition from early research to CMC development.</span> </span></p></li><li><p><span><span>Develop scalable, robust, and reproducible processes for payload linker</span><span> synthesis</span><span>, enabling seamless technology transfer from development labs to GMP manufacturing.</span> </span></p></li><li><p><span><span>Build and strengthen internal capabilities by developing team </span><span>expertise</span><span>, infrastructure, and technologies related to payload linker process development.</span> </span></p></li><li><p><span><span>Stay </span><span>current</span><span> of emerging technologies and scientific advancements in ADC linker and payload chemistry to </span><span>maintain</span><span> competitive edge.</span> </span></p></li><li><p><span><span>Champion a strong safety culture in all </span><span>laboratory</span><span> activities, ensuring proper handling, containment, and risk assessment practices for highly potent compounds.</span> </span></p></li><li><p><span><span>Provide technical guidance and career development support to team members, including goal setting, performance evaluations, and skills enhancement.</span></span></p></li><li><p><span><span>Manage external collaborations with vendors and CDMOs specializing in linker and payload synthesis and process development.</span> </span></p></li><li><p><span><span>Ensure compliance with regulatory guidelines and support filing activities for INDs, BLAs, and other regulatory submissions.</span></span></p></li></ul><p></p><p><span><span>​</span></span><b><span>Basic Requirements: </span></b><span> </span></p></div><div><div><div><ul><li><p><span><span>Ph</span><span>.</span><span>D.</span><span> in synthetic organic chemistry</span><span> or relevant scientific discipline</span><span> with &gt; </span><span>8 years of experience;</span><span> </span><span>B.S. or M.S. with 15&#43; years of </span><span>demonstrated</span><span> equivalent experience in a related field of </span><span>expertise</span><span>. </span></span><span> </span></p></li><li><p><span><span>Proven leadership experience managing </span><span>small molecule </span><span>CMC development programs and leading scientific teams through all stages of developmen</span><span>t f</span><span>rom discovery handoff to GMP manufacturing and regulatory submission.</span></span><span> </span></p></li><li><p><span><span>Extensive </span><span>expertise</span><span> and scientific knowledge in linker design, payload chemistry, and related bioconjugation strategies.</span></span></p></li><li><p><span><span>Proven ability to drive innovation in </span><span>ADC or small molecule </span><span>process development, with a focus on implementing novel technologies, improving efficiency, and solving complex scientific challenges.</span> </span></p></li><li><p><span><span>Experience in preparing and contributing to regulatory filings, including IND, IMPD, and BLA submissions, with responsibility for drafting and reviewing CMC-related documentation.</span></span></p></li></ul><p></p><p><b><span>Additional Skills/Preferences: </span></b><span> </span></p><ul><li><p><span><span>Experience working in high-potency laboratory environments, including the development of containment strategies and implementation of occupational safety practices, is highly desirable.</span> </span></p></li><li><p><span><span>Experience working with ADC projects, especially </span><span>regarding</span><span> the unique CMC and regulatory considerations, is a plus</span><span>.</span> </span></p></li><li><p><span><span>Strong leadership skills with </span><span>a track record</span><span> of building, mentoring, and </span><span>retaining</span><span> high-performing technical teams.</span> </span></p></li><li><p><span><span>Excellent cross-functional collaboration and communication skills; able to influence without authority and align internal and external stakeholders.</span> </span></p></li></ul><p></p><p><b><span>Additional Information:</span></b></p></div></div><div><div><p></p><p><b><span>Physical Demands/Travel:</span></b></p><p><span><span>The physical demands of this job are consistent with a<span> lab and office</span> environment<b>.   </b></span></span></p><p><span><i><span>The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.</span></i></span></p><p></p><p><span><b><span>Work Environment:</span></b></span></p><p><span><span>This position’s work environment is in <span>a</span> <span>laboratory and office environment.  </span></span></span></p><p><span><i><span>The</span></i></span><span><span> <i>work</i> <i>environment</i> <i>characteristics</i> <i>described</i> <i>here</i> <i>are</i> <i>representative of those an employee encounters while performing the essential functions of this job.</i></span></span></p><p><span><i><span>*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.</span></i></span></p></div></div></div><p style="text-align:left">Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (<a target="_blank" href="https://careers.lilly.com/us/en/workplace-accommodation"><span><span><span class="WCO0">https://careers.lilly.com/us/en/workplace-accommodation</span></span></span></a>) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.</p><p style="text-align:inherit"></p><p style="text-align:left">Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.</p><p style="text-align:left"><br />Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ&#43; Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.</p><p style="text-align:inherit"></p><p style="text-align:inherit"></p><p style="text-align:left">Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is</p>$159,000 - $233,200<p style="text-align:inherit"></p><h3></h3><p style="text-align:left">Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.</p><p style="text-align:inherit"></p><p style="text-align:left">#WeAreLilly</p>