Senior/Principal Scientist, Computational Biology

About Cellular Intelligence Cellular Intelligence (CI) is an AI-native TechBio company building a universal foundation model of cell signaling to understand, predict, and ultimately control cellular behavior, transforming biology from trial-and-error into an engineering discipline. We take a full-stack approach, generating perturbation data at over 1,000x the efficiency of conventional methods, capturing millions of time-resolved treatment combinations per experiment, and training large-scale models that generalize across contexts to enable rational protocol design for regenerative medicine, context-specific drug effect prediction, and systematic disease modeling. Our founding team includes repeat AI entrepreneur Dr. Micha Breakstone (Chorus.ai http://Chorus.ai, acquired for $575M), the Head of the Fundamental AI Group at MIT, and four professors from Harvard Medical School and the University of Washington, including the Chair of Genetics at Harvard, collectively holding five National Academy memberships. Based in Boston, CI has raised over $60M to date from Khosla Ventures, CZI, SciFi VC, and AMD Ventures, and is rapidly scaling its world-class team. Cellular Intelligence's Core Values: - We show up – fully accountable, all-in, doing whatever it takes - We act with urgency – swift, decisive, proactive - We support one another – collaborative, helpful, empathetic Location: Boston, MA (onsite, full-time) About the Role: As a Senior Computational Biologist, you will play a key role in creating pipelines, models and performing research over large scale single cell datasets. This role is ideal for someone who is passionate about large-scale transcriptomic data that will be used to create groundbreaking cell replacement technologies. You will work at the intersection of developmental biological research, data science, and software development, contributing to single-cell and spatial transcriptomics analysis, translating scientific discoveries into cutting edge cell replacement therapies.  Responsibilities: - Drive new research directions at the interface of bioinformatics and AI-powered stem cell biology - Develop and optimize computational biology pipelines for preprocessing, analysis, modeling and interpretation of high-dimensional transcriptomic data - Stay at the forefront of computational biology, keeping up with state-of-the-art techniques in developmental biology, single-cell multi-modal analysis and spatial transcriptomics - Operate autonomously in a fast-moving startup, helping shape Cellular Intelligence’s computational biology roadmap - Mentor and provide technical guidance to team members, fostering collaboration and knowledge sharing across disciplines - Collaborate closely with other computational biologists, machine learning researchers, and software engineers to build robust, scalable solutions Qualifications: - PhD in Computational Biology, Bioinformatics, Computer Science, or a related field - 3+ years of experience analyzing large-scale genomic and transcriptomic datasets, such as single cell RNA-seq and spatial omics - Solid computational and statistical skills, with demonstrated experience in high-dimensional biological data analysis - Strong programming skills and experience developing robust products, preferably in Python - Passion for data-driven biology and its potential to transform healthcare Preferred Qualifications: - Strong domain knowledge in developmental biology or stem cell research (highly advantageous) - 2+ years of experience in non-academic industry setting  - Prior experience in a startup or fast-paced environment - Experience in machine learning, and and developing models over biological data  - Strong publication record in top journals  Benefits: - Take a technical leadership role with a mission-driven company with the potential to significantly impact the lives of millions - Work alongside a talented and passionate team at the forefront of AI and cellular biology - Contribute to the development of groundbreaking therapies that address significant unmet medical needs - Enjoy a competitive salary and benefits package, including flexible work options Exceptional candidates who demonstrate outstanding capabilities and potential will be considered, even if they do not meet every qualification listed. Join us and help unlock the full potential of AI for the benefit of human health! Cellular Intelligence is committed to equal employment opportunity and non-discrimination for all employees and applicants regardless of race, color, ancestry, sex, sexual orientation, age, religion, national origin, ancestry, genetic information, disability, veteran status, marital status, citizenship status, or any characteristic protected under applicable law.