Senior Vice President, Late-Stage Clinical Development

The Opportunity:

The Senior Vice President, Late-Stage Clinical Development is one of the most visible and influential leadership roles in the company. Reporting to the Chief Medical Officer and sitting at the top of the late-stage clinical development organization, this executive plays a key role in shaping how the portfolio evolves. The person in this seat drives the future value of the company from a compound perspective.

The role arrives at an inflection point. With the first medicine approved and multiple registrational programs running in parallel, the company is moving from a single approved product to a multi-asset, multi-indication late-stage portfolio. This leader drives the overall clinical development strategy, maps out the plan that carries the portfolio forward in partnership with the Chief Medical Officer, and owns the registrational and Phase 3 programs across every asset. The Global Development Team Leads across the portfolio report to this executive.

Much of the substance of the job is working through the Global Development Team Leads to shape the trials, interpret emerging data, and decide how to change standard of care in tumors that have resisted it. The leader is also accountable for the structure and development of the late-stage organization: hiring and developing team leads who build their own teams, and aligning clinical scientists to the programs they support.

Visibility extends well beyond the development organization. This executive works directly with the Chief Medical Officer and Chief Development Officer on portfolio strategy, represents Revolution Medicines externally with clinical collaboration partners, with the potential to co-chair a joint steering or joint development committee, and can take leadership of a disease-area franchise. This is intended as a long-term seat, with scope expected to grow as the organization and the portfolio expand.

Key Responsibilities

• Drive the late-stage clinical development strategy across the RAS(ON) portfolio and map it into an integrated company development plan with the Chief Medical Officer.

• Own registrational and Phase 3 trials across all programs and assets, from design through readout and submission support.

• Shape indication sequencing, study design, endpoint selection and combination strategy with research, regulatory, biometrics and commercial leadership.

• Lead, develop and grow the Global Development Team Leads, and guide the construction and defense of their clinical development plans.

• Build a late-stage organization with clear program ownership, structured so that team leads hire and lead their own teams.

• Partner with regulatory affairs on global filings, health authority interactions and lifecycle planning.

• Partner with the Chief Medical Officer and Chief Development Officer on portfolio strategy and prioritization.

• Represent the company with clinical collaboration partners, with the potential to co-chair a joint steering or joint development committee.

• Engage investigators, key opinion leaders and the broader oncology community on the company's late-stage programs and data.

Required Skills, Experience and Education:

• MD or MD/PhD, trained as a medical oncologist.

• Substantial late-stage oncology development experience, including accountability for registrational and Phase 3 programs and global regulatory filings.

• Depth in pancreatic, colorectal or lung cancer strongly preferred.

• Track record leading development teams across multiple concurrent assets.

• Demonstrated ability to build and structure a clinical development organization, including hiring program leaders and layering teams beneath them.

• Strong scientific judgment and the credibility to guide experienced development leaders.

• Effective operating in a fast-moving, evolving organization, and comfortable building alignment across senior stakeholders

• Motivated by pipeline impact and the opportunity to change standard of care in difficult tumors.

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