Senior Scientist/Principal Scientist, DMPK

<br><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><b><span style="font-size:22pt;"><span style="line-height:31.386667px;"><span style="color:#6a6a6a;">Senior Scientist/Principal Scientist, DMPK</span></span></span></b></span></span></span></span></span></span></span></span><br><br><span style="font-size:11pt;"><span style="line-height:normal;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><span style="color:#6a6a6a;">Tenvie is a biotechnology company committed to engineering small molecules that transform the treatment of neurological diseases. The company&#8217;s foundation is purpose-built with a diverse portfolio of small molecules and a proven team of CNS drug developers to rapidly deliver multiple clinical assets. Tenvie is advancing a pipeline of therapeutics focused on treating neurological, cardiometabolic, and ophthalmic diseases. Its portfolio of wholly owned, highly brain-penetrant, and precision-designed peripherally restricted small molecules address three key drivers of disease: resolving inflammation, rescuing metabolic dysfunction, and restoring lysosomal function. The company&#8217;s most advanced programs target NLRP3 and SARM1, with additional programs in preclinical development.</span></span></span></span></span></span></span></span></span><br><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><span style="color:#6a6a6a;">We are looking for a highly motivated and skilled DMPK Scientist with expertise in small molecule drug discovery and early development. Reporting to the Senior Director, DMPK &amp; Clinical Pharmacology, this role will represent the DMPK function on projects, guiding and implementing strategies and enabling timely data-driven decision-making throughout the life cycle of small molecule therapeutics.&#160; Key deliverables are human PK and efficacious dose predictions and clinical risk assessment based on translating in vitro and nonclinical data.&#160; This is an excellent opportunity to join a biotech company with groundbreaking work in the field.&#160; This role is onsite.</span></span></span></span></span></span></span></span></span><br><br><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><span style="color:#6a6a6a;">JOB RESPONSIBILITIES:</span></span></span></span></span></span></span></span></span><ul><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Be a key contributor and subject matter expert to DMPK strategy applied to small molecule drug discovery through development by acting on interdisciplinary project teams</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Manage and oversee external vendors for completing in vitro and in vivo studies</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Contribute to the design and conduct of preclinical in vivo studies, and interpretation of data by building and implementing PK and PK/PD modeling and simulation and sensitivity analysis</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Establish close partnerships with biology, pharmacology, toxicology, biomarker, and clinical for providing human dose predictions and therapeutic index</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Oversee transfer of modeling strategies from preclinical space to implementation in clinical development</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Effectively communicate DMPK data and its interpretation for decision-making to project teams</span></span></span></span></li><li style="margin-left:8px;"><span style="font-size:11pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#6a6a6a;">Serve as a subject matter expert to write Nonclinical Pharmacology sections of regulatory (IND/CTA) filings, IB updates, and responses to regulatory queries</span></span></span></span></li></ul><br><br><br><br><br><br><br><br><br><br><span style="font-size:11pt;"><span style="line-height:normal;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><span style="background:#FFFFFF;"><span style="color:#6a6a6a;">QUALIFICATIONS:&#160; </span></span></span></span></span></span></span></span></span></span><ul><li style="margin-left:8px;margin-top:11px;margin-bottom:5px;"><span style="font-size:14pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#322d67;"><span style="font-weight:normal;"><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="color:#6a6a6a;">MS or PhD in Drug Metabolism, Pharmacokinetics, Chemistry, or related scientific discipline with a minimum 5+ years of pharmaceutical drug discovery and development experience or BSc with 10+ years of experience</span></span></span></span></span></span></span></span></li><li style="margin-left:8px;margin-top:11px;margin-bottom:5px;"><span style="font-size:14pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#322d67;"><span style="font-weight:normal;"><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="color:#6a6a6a;">Excellent critical thinking and scientific skills with proven scientific expertise in small molecule metabolism and pharmacokinetics</span></span></span></span></span></span></span></span></li><li style="margin-left:8px;margin-top:11px;margin-bottom:5px;"><span style="font-size:14pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#322d67;"><span style="font-weight:normal;"><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="color:#6a6a6a;">Demonstrated success working effectively and collaboratively on cross-functional projects teams</span></span></span></span></span></span></span></span></li><li style="margin-left:8px;margin-top:11px;margin-bottom:5px;"><span style="font-size:14pt;"><span style="line-height:107%;"><span style="font-family:Arial, sans-serif;"><span style="color:#322d67;"><span style="font-weight:normal;"><span style="font-size:11pt;"><span style="line-height:15.693334px;"><span style="color:#6a6a6a;">Excellent oral presentation and written communication skills</span></span></span></span></span></span></span></span></li></ul><h3 style="margin-top:11px;margin-bottom:5px;"></h3><h3 style="margin-top:11px;margin-bottom:5px;"><span style="font-size:14pt;"><span style="line-height:normal;"><span><span style="font-family:Arial, sans-serif;"><span style="color:#322d67;"><span style="font-weight:normal;"><span style="font-style:normal;"><span style="white-space:normal;"><span style="text-decoration:none;"><span style="font-size:11pt;"><span style="color:#6a6a6a;">Expected salary range:</span></span></span></span></span></span></span></span></span></span></span></h3><ul><li style="margin-bottom:11px;"><span style="font-size:11pt;"><span style="background:#FFFFFF;"><span style="color:#6a6a6a;"><span style="line-height:normal;"><span><span style="font-family:Arial, sans-serif;"><span style="font-size:10.5pt;"><span style="background:#FFFFFF;">$160,000-200,000 annual base salary</span></span></span></span></span></span></span></span></li></ul><br><span style="font-size:11pt;"><span style="line-height:normal;"><span style="font-family:Arial, sans-serif;"><span style="color:#000000;"><span style="font-style:normal;"><span style="font-weight:400;"><span style="white-space:normal;"><span style="text-decoration:none;"><i><span style="color:#6a6a6a;">Tenvie is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit and business need.</span></i></span></span></span></span></span></span></span></span><br>&#160;