Senior Scientist, Organoid

Experience level: PhD plus postdoctoral training or equivalent industry experience (typically 3+ years post-PhD). About Conception Conception is pioneering the future of reproductive biology by generating functional human eggs from induced pluripotent stem cells (iPSCs). Our mission is to unlock new possibilities for fertility, reproductive health, and genetic diversity. We are building a world-class team at the intersection of stem cell biology, developmental biology, and synthetic biology to make this vision a reality. The position We are seeking an exceptionally strong, hands-on senior scientist to help drive scientific progress in the development and application of advanced 3D organoid model systems. In this role, you will lead efforts to develop, optimize, and implement protocols that enable our organoids to more faithfully recapitulate the native tissue niche, improving their biological relevance and utility. You will also work closely with cross-functional project teams pursuing related scientific objectives, translating discoveries, sharing technical learnings, and helping integrate model system advances across programs. This position is ideal for someone who is both scientifically rigorous and highly collaborative, with a strong interest in building physiologically relevant systems that can accelerate discovery and translational impact. The most successful candidate will bring hands-on experience developing new differentiation protocols, strong tissue engineering expertise, and a deep understanding of how cellular microenvironments influence tissue identity, maturation, and function. What you’ll do - Independently design, develop, and optimize differentiation and tissue engineering protocols that improve organoid fidelity, maturation, reproducibility, and relevance to the native tissue niche - Lead day-to-day execution while mentoring and developing scientists, setting expectations for rigor, documentation, and pace - Synthesize experimental results, communicate progress clearly to scientific and program leadership, and help guide strategic decisions for platform and program development - Collaborate closely with cross-functional project teams to share findings, integrate complementary approaches, and advance common objectives across related model system efforts - Foster a team culture grounded in curiosity, urgency, flexibility, technical excellence, and transparency What we’re looking for - PhD in Stem Cell Biology, Developmental Biology, or a related field, plus postdoctoral training or equivalent industry experience - Experience with organoid microenvironment manipulation or bioengineering of tissue and/or organoid model systems - Deep hands-on expertise in troubleshooting differentiation trajectories and complex model systems. Ideally expertise in setting up model systems; not just optimizing an already established protocol - Exceptionally strong organizational and communication skills including thorough record keeping and priority-aligned executive summarization - Ability to drive project direction and prioritize based on company goals - Strong analytical skills including experience interpreting sequencing datasets (SmartSeq2, single-cell RNA-seq, ATAC-seq, EM-seq, or similar) - Strong work ethic and team-first mindset. Willing to do hands-on work, including routine and repetitive tasks, and step in when needed - Able to thrive in a high-intensity, fast-paced, flexible startup environment - Familiarity with reproductive biology, particularly ovarian development and the germ cell lifecycle, is a plus Why join us - Impact: Own one of Conception’s most critical preclinical programs, with the potential to transform human reproduction - Ownership: Operate with autonomy in a fast-moving biotech startup and build a program end-to-end - Growth: Develop and lead a small team and expand scope as the program scales - Community: Work alongside passionate scientists tackling one of the most exciting frontiers in biology with a deeply aligned team - Mission: Build the biological foundation for a new era of reproductive medicine, expanding what is possible for millions of people and families with limited options today Come and work with us We are well funded and well connected in Silicon Valley. We offer competitive pay, company equity, and excellent healthcare benefits for these positions. ‍To learn more about the original mouse proof of concept to live birth that inspired us, seehttps:// https://www.nature.com/articles/nature20104www.nature.com/articles/nature20104 http://www.nature.com/articles/nature20104