Senior Scientist, LNP MSAT

<p style="text-align:left"><u><b>Job Description:</b></u></p><p style="text-align:inherit"></p><p><b>Company Overview</b></p><p>Since its inception over a decade ago, CRISPR <span><span><span>Therapeutics has</span></span></span> transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR <span><span><span>Therapeutics has</span></span></span> established strategic partnerships with leading companies including Vertex <span><span><span>Pharmaceuticals. CRISPR</span></span></span> Therapeutics AG is headquartered in Zug, Switzerland, with its <span><span><span>wholly-owned U.S. subsidiary, CRISPR</span></span></span> Therapeutics, Inc., and R&amp;D operations based in Boston, <span><span><span>Massachusetts and San</span></span></span> Francisco, California, and business offices in London, United Kingdom.</p><p></p><p><b>Position Summary</b></p><p>If you enjoy challenges, are eager to learn, and want to join a team working on the next generation of gene editing therapeutics, we&#39;d love to hear from you. Our ideal candidate will possess practical experience in tech transfer and large-scale LNP manufacturing, along with a strong understanding of process engineering principles.</p><p></p><p><b>Responsibilities</b></p><ul><li> Support the manufacturing operation at the CDMO</li><li>Manage, support, and lead the technology transfer of products into manufacturing facilities</li><li>Troubleshoot manufacturing events, perform root cause analysis, and implement corrective actions for process deviations</li><li>Analyze process data, monitor process performance against metrics, and present experimental or manufacturing data to a wide range of audiences</li><li>Collaborate with QA, QC, PD, AD, RA, and other teams to ensure operations are compliant</li><li>Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate</li><li> Work closely with CDMO partners, providing technical oversight and taking the lead in supporting investigations and resolving deviations</li><li>Author and review technical sections for regulatory submissions</li><li>Analyze process and manufacturing data to understand and optimize process performance</li><li>Author and review technical reports and master and executed batch records, working across internal teams and with CDMO partners</li><li> Build strong, effective relationships with colleagues across diverse backgrounds and areas of expertise</li><li>Excellent interpersonal and communication skills; collaborative, solutions-oriented, and willing to contribute where needed</li></ul><p></p><p><b>Minimum Qualifications</b></p><ul><li>Ph.D. in biology, bioengineering, chemical engineering, or a related discipline, and 5-7&#43; years of professional experience or bachelor’s degree with 10&#43; years of professional experience</li><li>Outstanding problem-solving skills and a willingness to think outside the box.</li><li>Prior experience with gene editing and manufacturing of lipid nanoparticles (LNPs).</li><li>Expertise in manufacturing, tech transfers, and deviations.</li><li>Excellent writing, reviewing, and presentation skills.</li><li>Thorough knowledge of cGMP, ISO, and ICH guidelines and industry best practices.</li><li>Ability to work independently and collaboratively in a results-oriented environment.</li><li>Must possess critical thinking and self-reliance to solve tasks independently.</li></ul><p></p><p><b>Preferred Qualifications</b></p><ul><li>Self-motivated and scientifically rigorous, with outstanding organizational and multitasking skills.</li><li>Entrepreneurial spirit, including resourcefulness, accountability, agility to pivot, transparency, and productivity.</li><li>Ability to keep pace with a fast-moving organization</li></ul><p></p><p><b>Competencies</b></p><ul><li><span>Collaborative – Openness, One Team</span></li><li><span>Undaunted – Fearless, Can-do attitude</span></li><li><span>Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.</span></li><li><span>Entrepreneurial Spirit – Proactive. Ownership mindset.</span></li></ul><p><span>CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.</span></p><p></p><p>Senior Manager: <span>Base pay range of $137,000 to $150,000&#43; bonus, equity and benefits</span></p><p><span>The range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.</span></p><p></p><p></p><p><span>CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person&#39;s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. </span></p><p></p><p><span>To view our Privacy Statement, please click the following link:</span> <a href="http://www.crisprtx.com/about-us/privacy-policy" target="_blank">http://www.crisprtx.com/about-us/privacy-policy</a></p>