Senior. Scientist, In Vivo Pharmacology

Job Description

The In Vivo Pharmacology – Oncology group within the Department of Quantitative Biosciences (QB) is seeking a Senior Scientist with deep experience in cancer biology and in vivo models to join our Boston-based Discovery team.  The successful candidate will be an experienced In Vivo cancer biologist who will be involved in hands-on work advancing oncology reverse-translational activities  while serving as a key contributor in the conception and execution of Oncology drug discovery projects. This role will involve cross collaboration with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies (e.g., spatial biology using novel multi-plex immunohistochemistry capabilities), and interfacing with our global pharmacology network.  The successful applicant will also have the skill sets to work closely with teams in different functional area teams (e.g., Bioinformatics, Discovery Chemistry, and Discovery Biologics) in a highly matrixed system.

The successful Senior Scientist candidate will:

• Directly contribute to reverse translational efforts through hands-on experimentation using preclinical models and ex vivo techniques  (xenografts/GEMMS, etc.).

• Advance our Oncology pipeline through performing in vivo pharmacology studies, designed to deepen our understanding of PK/PD and efficacy relationships.

• Thrive in a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.

• Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.

QUALIFICATIONS:

Education:

• Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. in Oncology, Pharmacology, Biology, Biotechnology, Molecular and Cell Biology, or related STEM field with relevant experience in drug discovery

Required Experience and Skills:

• Experience using preclinical models to evaluate the in vivo pharmacology of novel modality-agnostic oncology drugs (small molecules, antibodies, ADCs, TCEs etc).

• Proficiency in animal handling techniques, including restraint, blood sample collection, and various routes of administration (I.V., PO, IP etc.).

• Experience with multi-plex and spatial biology capabilities including, but not limited to, flow cytometry, immunohistochemistry, imaging mass cytometry, and PhenoCycler-Fusion.

• Proficiency in complex problem-solving and the ability to influence strategy through generation of high-quality data.

• Strong skills in effective communication, collaboration, balanced risk-taking, and a high level of organization.

 #EligibleforERP 

Required Skills:

Animal Handling, Cancer Biology, Cancer Research, Drug Discovery Process, Flow Cytometry, Imaging Techniques, Immunohistochemistry (IHC), In Vivo Models, In Vivo Pharmacology, Mass Cytometry, Multiplexing, Oncology

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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The salary range for this role is

$119,100.00 - $187,500.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

05/21/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.