Key Responsibilities and Activities
- Design, develop, and execute cell-based bioassays to evaluate performance of investigative drugs (biologics)
- Stay updated with cutting edge discoveries and trends and contribute to the company’s R&D strategy to generate and test actionable development plans
- Identify emerging methods, tools, and biology approaches, and implement them when applicable
- Function as a key team member, and simultaneously train and supervise associates on the R&D team
- Collaborate closely with other scientists and research associates on the R&D team
- Contribute to work with external parties, including academic collaborators and CROs to create comprehensive capabilities for MoA, target validation and potency studies
- Write clear and concise research reports and ensure study documentation and update protocols to ELN
- Participate and contribute to internal discussions and meetings
- Present results to the project leadership team and management in an organized and timely manner
Required Education, Experience, Skills and Competencies
- Ph.D. in Cellular Biology, Immunology, or a relevant discipline
- At least 2 years of industry research experience
- Extensive experience working with different types of in vitro systems such as immune cells, epithelial cells, fibroblasts, endothelial cells, and other cell lines
- Strong background with cell-based assays to interrogate immune pathway activation, immune suppression, cytotoxicity, antibody mediated cell killing
- Broad skillset for target validation, potency evaluation and MoA interrogations is highly desired, including the use of tissue culture approach with multiple readouts, flow cytometry, ex-vivo studies, use of gene knockdown tools, conventional immunoassays, phosphorylation analysis and conventional pulldown assays.
- Hands on ability to execute wet lab experiments, data processing, and ability to effectively communicate key scientific findings across the organization
- Ability to establish and maintain cooperative working relationships with co-workers and other stakeholders
- Ability to adjust to workload changes and prioritize competing demands
- Ability to balance the big picture and fine technical details
- Outstanding organizational, critical thinking, and problem-solving skills
- Excellent written and verbal communication skills