Senior Scientist, Biologics Design and Display, Discovery Biologics

Job Description

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.

We are seeking a Senior Scientist to join Biologics Design and Display team in the Boston Discovery Biologics group.  The successful candidate will be an integral member of the team responsible for conducting in vitro display campaigns to generate novel therapeutic hits and optimized leads. They will directly contribute to the discovery of novel biologics as well as platform build and technology optimization efforts. They will stay current with scientific progress and drive continuous innovation of display technologies to consistently deliver high quality early biologics to support drug discovery across multiple therapeutic areas. As part of project teams, they will collaborate across groups to solve complex problems in disease biology and drug discovery.  They will attend scientific conferences, contribute to publications, train and mentor junior stuff and interns, and help to set the group strategy. 

We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees.  Successful candidates must demonstrate inclusive behaviours in working with a diverse group of researchers to drive our core mission.

Responsibilities:

• Perform yeast and phage display based biologics discovery screens to support therapeutic programs

• Execute display-based lead optimization, including display library building, QC, and screening

• Contribute to design and building of novel display libraries

• Routinely use NGS, including NGS library generation, QC, sequencing and data analysis, for hit selection

• Maintain accurate data and experimental records 

• Prepare presentations to effectively communicate experimental results in team meetings

• Collaborate across different functional areas within Discovery Biologics and with key stakeholders in other departments

• Stay abreast of external advancements in the relevant scientific fields

• Promote the external reputation of our company’s Discovery Biologics

 

Qualifications & Experience

• PhD in Biology, Biochemistry, Analytical Chemistry, Bioengineering, Biophysics, Protein Sciences, Pharmaceutics, or a related life sciences discipline with 0-3 years of experience or MS with >5 years of industry experience

• Expertise in using display-based screening methods

• Expertise in molecular biology and high throughput laboratory methodologies

• Strong presentation and publication record

 

Required skills:

• Deep expertise in both phage and yeast display

• Hands on experience in antibody or other molecular display technologies

• Expertise in NGS technology, including NGS libraries generation, QC, sequencing and sequence analysis

• Strong technical knowledge of molecular biology

• Strong analytical and problem solving skills

• Stay abreast of external advancements in the relevant scientific fields

• Excellent communication and organizational skills

 

Preferred skills:

• Hands on expertise in display library design and generation

• Knowledge of computational and structure-guided approaches in display library design

• Knowledge of antibody discovery technologies beyond display

• Hands on expertise in using laboratory automation

#EligibleforERP

Required Skills:

Antibodies, Antibody Discovery, Display Technologies, High-Throughput Screening, Molecular Biology Techniques, Next Generation Sequencing (NGS), Phage Display, Yeast Display

Preferred Skills:

Automation

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The salary range for this role is

$119,100.00 - $187,500.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

OEB4

Job Posting End Date:

05/8/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.