Senior Scientist, Binder Design and Development

<p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">What if…</span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)"> you could pioneer </span><span data-ccp-parastyle="Normal (Web)">a new approach</span><span data-ccp-parastyle="Normal (Web)"> to designing life's most essential molecules</span><span data-ccp-parastyle="Normal (Web)">?</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">FL</span><span data-ccp-parastyle="Normal (Web)">116</span><span data-ccp-parastyle="Normal (Web)">,</span><span data-ccp-parastyle="Normal (Web)"> backed by Flagship Pioneering, is an early-stage biotechnology company transforming the way </span><span data-ccp-parastyle="Normal (Web)">biomolecules </span><span data-ccp-parastyle="Normal (Web)">are synthesized</span><span data-ccp-parastyle="Normal (Web)">.</span><span data-ccp-parastyle="Normal (Web)"> </span><span data-ccp-parastyle="Normal (Web)">Our innovative platform has the potential to transform the way these critical research</span><span data-ccp-parastyle="Normal (Web)">, diagnostic, and therapeutic</span><span data-ccp-parastyle="Normal (Web)"> tools are manufactured</span><span data-ccp-parastyle="Normal (Web)">.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">We are </span><span data-ccp-parastyle="Normal (Web)">seeking</span><span data-ccp-parastyle="Normal (Web)"> a creative, motivated, and technically exceptional </span></span><span data-contrast="auto"><span data-ccp-charstyle="Strong">Senior Scientist</span></span><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong"> </span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">to lead the design, development, and screening of peptide and protein-based binders targeting small-molecule substrates. This individual will build and scale high-throughput workflows for binder discovery, affinity characterization, and functional validation, playing </span><span data-ccp-parastyle="Normal (Web)">a central role</span><span data-ccp-parastyle="Normal (Web)"> in shaping a novel molecular control platform.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">This is a rare opportunity to build foundational technology within a deeply integrated, fast-moving startup backed by Flagship’s venture creation engine.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Position Summary</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-charstyle="Strong">S</span></span><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">enior Scientist</span><span data-ccp-parastyle="Normal (Web)"> </span><span data-ccp-parastyle="Normal (Web)">– </span><span data-ccp-parastyle="Normal (Web)">Peptide & Protein Binder Design and Development</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">The Senior</span><span data-ccp-parastyle="Normal (Web)"> Scientist</span><span data-ccp-parastyle="Normal (Web)"> will lead efforts to design, engineer, express, and characterize genetically encoded peptide and protein binders against defined small-molecule targets. This role spans the full discovery workflow</span><span data-ccp-parastyle="Normal (Web)">, </span><span data-ccp-parastyle="Normal (Web)">from scaffold selection and library design,</span><span data-ccp-parastyle="Normal (Web)"> to assay development, high-throughput expression, affinity screening, and hit-to-lead optimization.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">The ideal candidate is a hands-on protein</span><span data-ccp-parastyle="Normal (Web)">/peptide</span><span data-ccp-parastyle="Normal (Web)"> engineer with deep </span><span data-ccp-parastyle="Normal (Web)">expertise</span><span data-ccp-parastyle="Normal (Web)"> in binder discovery platforms and quantitative biophysical characterization. They are comfortable building scalable screening systems, handling large datasets, and iterating rapidly through design–build–test–learn (DBTL) cycles</span><span data-ccp-parastyle="Normal (Web)"> with machine learning / computational support.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Key Responsibilities</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Lead the design and engineering of peptide and protein-based binders targeting small-molecule substrates, </span><span data-ccp-parastyle="Normal (Web)">leveraging</span><span data-ccp-parastyle="Normal (Web)"> rational design, library construction, and directed evolution strategies.</span></span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Build and execute high-throughput discovery and screening workflows, including display-based selection platforms and scalable expression systems capable of evaluating large variant libraries.</span></span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Develop and apply quantitative biophysical assays (e.g., BLI, SPR, FP, ITC) to generate affinity curves, </span><span data-ccp-parastyle="Normal (Web)">determine</span><span data-ccp-parastyle="Normal (Web)"> kinetic parameters (</span><span data-ccp-parastyle="Normal (Web)">kon</span><span data-ccp-parastyle="Normal (Web)">/</span><span data-ccp-parastyle="Normal (Web)">koff</span><span data-ccp-parastyle="Normal (Web)">), calculate KD values, and </span><span data-ccp-parastyle="Normal (Web)">establish</span><span data-ccp-parastyle="Normal (Web)"> selectivity profiles.</span></span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Drive iterative design–build–test–learn (DBTL) campaigns, integrating affinity and functional data with computational modeling to rapidly </span><span data-ccp-parastyle="Normal (Web)">optimize</span><span data-ccp-parastyle="Normal (Web)"> binder performance.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Provide scientific and strategic leadership within the binder engineering workstream, contributing to IP development, cross-functional collaboration, and the establishment of a rigorous, high-velocity experimental culture.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Qualifications</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Ph.D. in Protein Engineering, Biochemistry, Structural Biology, Molecular Biology, or related discipline.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">4+ years of relevant industry experience</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Demonstrated experience in protein or peptide binder discovery and optimization.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Hands-on </span><span data-ccp-parastyle="Normal (Web)">expertise</span><span data-ccp-parastyle="Normal (Web)"> in quantitative affinity screening (BLI, SPR, FP, ITC, or related technologies).</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Experience designing and executing high-throughput screening workflows.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Strong understanding of protein-ligand interaction principles and binding thermodynamics.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Proven ability to run iterative design–build–test cycles in a fast-paced environment.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Who You Are</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Innovative Pioneer:</span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)"> You thrive in breaking new ground scientifically and are passionate about </span><span data-ccp-parastyle="Normal (Web)">leveraging</span><span data-ccp-parastyle="Normal (Web)"> protein biochemistry to create transformative technologies.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Collaborative Contributor:</span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)"> You excel in cross-functional teams, readily share </span><span data-ccp-parastyle="Normal (Web)">expertise</span><span data-ccp-parastyle="Normal (Web)">, and value the input of colleagues.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Inventive Problem Solver:</span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)"> You proactively identify challenges and rapidly </span><span data-ccp-parastyle="Normal (Web)">ideate</span><span data-ccp-parastyle="Normal (Web)"> creative solutions.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">Mission-Driven Individual:</span></span></strong><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)"> You are driven by an ambition to fundamentally change how </span><span data-ccp-parastyle="Normal (Web)">biomolecules</span><span data-ccp-parastyle="Normal (Web)"> are synthesized and to meaningfully </span><span data-ccp-parastyle="Normal (Web)">impact</span><span data-ccp-parastyle="Normal (Web)"> human health and biotechnology.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li> </ul> <p><strong><span data-contrast="auto"><span data-ccp-charstyle="Strong">More About Flagship Pioneering</span></span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, generating billions in value. Flagship companies are known for addressing humanity’s most pressing challenges and advancing innovative solutions with global impact.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">We are an equal opportunity employer and are dedicated to building diverse and inclusive teams. If you have some of the qualifications listed </span><span data-ccp-parastyle="Normal (Web)">above</span><span data-ccp-parastyle="Normal (Web)"> but not all, we still encourage you to apply. We value passion, experience in many forms, and unique backgrounds.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Come pioneer the future with us.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p> </p> <p><strong><span data-contrast="auto">Recruitment & Staffing Agencies</span></strong><span data-contrast="auto">: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.</span><span data-ccp-props="{}"> </span></p> <p> </p><p id="pay-transparency" style="margin: 0 !important; padding: 0 !important; float: none !important; clear: both !important; display: block;">The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL116 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL116's good faith estimate as of the date of publication and may be modified in the future.</p>