Senior Research Associate, Drug Product

The Opportunity:

We have an opening for a full-time position as a Senior Research Associate position within the Drug Product function of our Pharmaceutical Development and Manufacturing (PDM) department. The position will be laboratory-based and responsible for preformulation studies, preclinical formulations development, and troubleshooting to support Revolution Medicines’ drug product development.

Responsibilities:

• Conduct solution and solid-state preformulation studies for RevMed research and development candidates (i.e. solubility, dissolution, excipient compatibility, stability studies, permeability and biopharmaceutics assessment, mechanical and processing properties).

• Conduct solid form related activities of new chemical entities during preclinical assessment and throughout the clinical development phases (ie. solid form screening, co-crystal and salt screening, solid form identification, and solid-state characterization).

• Support preclinical and (if needed) clinical formulation development.

• Collaborate with Research team and prepare preclinical formulations in a timely manner.

• Analyze formulations using suitable analytical methods to assess formulation stability, and dose analysis.

• Maintain good laboratory notebook record (i.e. ELN) to document formulation preparation process, test results, and lab activities.

• Help to maintain and manage lab activities, such as chemical inventories, calibrations, safety practices, new equipment acquisition, installation, and training.

• Conduct lab activities for troubleshooting formulation and solid form related issues.

• Write, revise, and update formulation protocols in a timely manner; support efforts to maintain and organize formulation protocols.

• Provide support to research and PDM organizations for requests related to API and formulations.

• Work closely with immediate supervisor on problems that may be of moderate complexity.

Required Skills, Experience and Education:

• BS with minimum 5 years or MS with minimum 3 years of the relevant laboratory experience in pre-formulation, formulation development, solid form screening, and analytical development.

• Proficient in laboratory analytical techniques, specifically in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements.

• Experience in preclinical formulation screening and development to support in-house formulation preparations and management.

• Good understanding of basic organic chemistry and analytical chemistry.

• Excellent communication skills and a collaborative team player.

• Highly organized with strong attention to detail and documentation skills.

• Ability to multi-task and thrive in a fast-paced innovative environment.

Preferred Skills:

• BS and/or MS degree in pharmaceutical sciences, chemistry, and chemical engineering, or related discipline.

• HPLC method development experience is preferred. 

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