Senior Research Associate, Drug Product

<p>Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.</p> <p><strong>The Opportunity:</strong></p> <p>We have an opening for a full-time position as a Senior Research Associate position within the Drug Product function of our Pharmaceutical Development and Manufacturing (PDM) department. The position will be laboratory-based and responsible for preformulation studies, preclinical formulations development, and troubleshooting to support Revolution Medicines’ drug product development.</p> <p>Responsibilities:</p> <ul> <li> <p>Conduct solution and solid-state preformulation studies for RevMed research and development candidates (i.e. solubility, dissolution, excipient compatibility, stability studies, permeability and biopharmaceutics assessment, mechanical and processing properties).</p> </li> <li> <p>Conduct solid form related activities of new chemical entities during preclinical assessment and throughout the clinical development phases (ie. solid form screening, co-crystal and salt screening, solid form identification, and solid-state characterization).</p> </li> <li> <p>Support preclinical and (if needed) clinical formulation development.</p> </li> <li> <p>Collaborate with Research team and prepare preclinical formulations in a timely manner.</p> </li> <li> <p>Analyze formulations using suitable analytical methods to assess formulation stability, and dose analysis.</p> </li> <li> <p>Maintain good laboratory notebook record (i.e. ELN) to document formulation preparation process, test results, and lab activities.</p> </li> <li> <p>Help to maintain and manage lab activities, such as chemical inventories, calibrations, safety practices, new equipment acquisition, installation, and training.</p> </li> <li> <p>Conduct lab activities for troubleshooting formulation and solid form related issues.</p> </li> <li> <p>Write, revise, and update formulation protocols in a timely manner; support efforts to maintain and organize formulation protocols.</p> </li> <li> <p>Provide support to research and PDM organizations for requests related to API and formulations.</p> </li> <li> <p>Work closely with immediate supervisor on problems that may be of moderate complexity.</p> </li> </ul> <p><strong>Required Skills, Experience and Education:</strong></p> <ul> <li> <p>BS with minimum 5 years or MS with minimum 3 years of the relevant laboratory experience in pre-formulation, formulation development, solid form screening, and analytical development.</p> </li> <li> <p>Proficient in laboratory analytical techniques, specifically in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements.</p> </li> <li> <p>Experience in preclinical formulation screening and development to support in-house formulation preparations and management.</p> </li> <li> <p>Good understanding of basic organic chemistry and analytical chemistry.</p> </li> </ul> <ul> <li> <p>Excellent communication skills and a collaborative team player.</p> </li> <li> <p>Highly organized with strong attention to detail and documentation skills.</p> </li> <li> <p>Ability to multi-task and thrive in a fast-paced innovative environment.</p> </li> </ul> <p><strong>Preferred Skills:</strong></p> <ul> <li> <p>BS and/or MS degree in pharmaceutical sciences, chemistry, and chemical engineering, or related discipline.</p> </li> <li> <p>HPLC method development experience is preferred. </p> <p class="p1"><span style="color: rgb(255, 255, 255);">#LI-Hybrid #LI-CT1</span></p> </li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p>The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.</p> <p>Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.</p> <p>Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.</p> <p>Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our <a href="https://www.revmed.com/ccpa-notice">CCPA Notice</a> and <a href="https://www.revmed.com/privacy-policy">Privacy Policy</a>. For additional information, please contact <a href="mailto:privacy@revmed.com">privacy@revmed.com</a>.</p></div><div class="title">Base Pay Salary Range</div><div class="pay-range"><span>$106,000</span><span class="divider">—</span><span>$126,000 USD</span></div></div></div><div class="content-conclusion"><hr> <p><em>We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.</em><br><em> </em><br><em>Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official <strong>@revmed.com</strong> email address.</em><br><em> </em><br><em>If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to <span style="color: rgb(35, 111, 161);"><strong>careers@revmed.com</strong></span> so we can share these impersonations with our IT team for tracking and awareness.</em></p> <hr> <p> </p></div>