Senior Research Associate, DMPK

The Opportunity:

As a key member of our dynamic DMPK lab team within DMPK under the non-clinical development and clinical pharmacology (NDCP) department, you will have responsibilities including, but not limited to:

• Develop LC-MS/MS methods and analyze in vivo and in vitro samples to support ADME, pharmacokinetic, efficacy, and toxicokinetic studies, etc.

• Handle a variety of tissues, including tumors, from tissue homogenization through sample preparation for bioanalysis.

• Perform data analysis, prepare experimental result reports, and upload data to electronic notebooks.

• Conduct in vitro ADME/DMPK assays in biological matrices, including hepatocytes, microsomes, blood, and plasma, ect.

• Support laboratory operations, including lab safety, LC-MS/MS instrument maintenance and troubleshooting.

Required Skills, Experience and Education:

• Bachelor’s or master’s degree in pharmaceutical sciences or a related scientific discipline, with 5+ years of industry experience for bachelor’s degree holders or 3+ years for master’s degree holders.

• Hands-on experience in operating and maintaining LC-MS/MS systems.

• Hands-on experience in LC-MS/MS method development and bioanalytical analysis.

• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS analysis.

• Hands-on experience in HPLC/UPLC method development.

• Ability to customize and follow established assay protocols.

• Ability to manage multiple laboratory and project tasks efficiently.

• Ability to work effectively in a flexible, team-oriented environment.

• Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.

Preferred Skills:

• Previous hands-on experience in SCIEX QTRAP mass spectrometers.

• Previous hands-on experiences on bioanalytical method development in compliance with regulatory requirements.

• Working experience in DMPK lab.

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