Senior / Principal Scientist in Pharmaceutical Development of Synthetic Molecules (Drug Product)

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

In PTD, we collaborate to develop robust manufacturing processes and quality control systems to efficiently transform scientific ideas into products. We reliably deliver quality products to patients enrolled in clinical studies around the world. We excel in our work by creating an engaging and inclusive environment where everyone can bring their skills and talents to developing innovative medicines.

This position is part of the Synthetic Molecule Pharmaceutical and Solid State Development organisation (PTDC-P). Within PTDC-P, we transform molecules to medicines through particle engineering, and develop and deliver customised clinical formulations and robust commercial drug products that benefit patients.

The Opportunity

As a Senior Scientist / Principal Scientist in Drug Product Development, you are responsible for developing robust formulations and lean manufacturing processes for oral dosage forms of new chemical entities. In this position, you work closely with international teams, including scientists and management from other disciplines (chemistry, analytics, quality, regulatory, and commercial production), and you represent the department on technical development teams (CMC) and scientific boards. Furthermore, you are driving scientific initiatives to ensure the department's scientific and technical excellence.

The main responsibilities of this challenging position include:

• Development and optimisation of clinical as well as commercial formulations and manufacturing processes for oral solid drug products using various manufacturing technologies (i.e. batch and continuous mode), including the scale-up and transfers to commercial manufacturing sites to facilitate the successful process validation at the sites.

• Development and implementation of new and innovative drug delivery technologies that can be applied in regular portfolio projects.

• Application of statistical tools (e.g. DoEs), risk assessment tools for QbD (e.g. QRA, FMEA) and Modelling and Simulation tools.

• Regular review of scientific literature to extract relevant trends and integrate innovative concepts and technologies in the scientific strategy of the department.

• Active participation in scientific teams at Roche as well as external consortia.

• Authorship and review of technical reports, manufacturing instructions, process validation documents, and the CMC parts of regulatory submissions to support market authorisation. 

• Contributing actively to the intellectual property values protection of our Roche products.

• Active sharing of own knowledge/experience with other scientists in regular exchange meetings and as a project consultant or mentor.

Who you are

• You hold a PhD or Master’s in Pharmaceutical Technology or Chemical/Process Engineering, backed by 5–10 years of experience in the development of oral dosage forms.

• You possess broad expertise in the drug product lifecycle, including the authorship of CMC regulatory dossiers and a preference for direct, professional interaction with health authorities.

• You excel at managing external partnerships, demonstrating a strong ability to lead and collaborate effectively with CDMOs.

• You are a results-driven innovator who applies "out of the box" thinking to implement technical solutions and remains highly adaptable to organisational change.

• You combine a coaching mindset with excellent communication skills, thriving as a fair team player who can work both independently and cross-functionally.

• You demonstrate a high degree of professional flexibility, including a willingness to travel occasionally to meet project and stakeholder needs.

Unwavering focus, collaborative teamwork and exceptional delivery are key behaviours that drive our mission of doing now, what patients need next. Together, we can be transformative.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you!

Every role at Roche plays a part in making a difference in patients’ lives. Apply now and join us in making an impact!

Please submit a CV and a Cover Letter to complete your application.

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.