Senior Manager, AI and Data Science

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title:  Senior Manager, AI and Data Science

Department: AI and Data Science

Location: Hybrid, Conshohocken PA

About Madrigal Pharmaceuticals

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Description

Madrigal Pharmaceuticals is advancing transformational therapies with scientific rigor and a commitment to patients. We are expanding our AI capabilities to accelerate insights, enhance decision quality, and enable scalable innovation across the organization. We are seeking a Senior Manager, AI and Data Science who brings strong technical depth, hands-on experience with agentic AI, and an ownership mindset. This individual will develop advanced AI solutions, partner across functions, and help expand our use of modern machine learning and agentic frameworks to support our mission.

Key Responsibilities

AI & Data Science Development

• Lead end-to-end development of machine learning and AI models, from problem framing through deployment and ongoing evaluation.
• Collaborate effectively with data scientists, ML engineers, and cross-functional partners to design and deliver AI solutions that support business and scientific needs.
• Work with stakeholders to identify high-value opportunities for AI that enhance Commercial, Medical, and enterprise-level processes.

Agentic AI & Framework Integration

• Build and optimize AI agents and orchestration workflows using modern agentic frameworks such as LangGraph, LlamaIndex, or CrewAI.
• Develop modular and reusable components for reasoning, retrieval, tool integration, and workflow automation.
• Develop end-to-end agentic frameworks incorporating agent connectors, MCP tools, and integrated interfaces, working closely with the Agentic UI team to ensure seamless product delivery.

Modeling & Applied Machine Learning

• Design and deploy machine learning models, including applications in recommendation, personalization, and other ML-driven decision-support systems.
• Apply modern ML techniques, including embeddings, graph methods, and generative model integration to real-world healthcare and Commercial challenges.
• Build AI solutions for Commercial use cases in Healthcare and Life Sciences.

Data Integration & MLOps

• Partner with data engineering teams to ensure scalable, ML-ready data pipelines and model monitoring.
• Utilize platforms such as Databricks to support model development, optimization, and operationalization.

Cross-Functional Engagement

• Translate complex AI concepts into clear, actionable insights for technical and non-technical partners.
• Align AI initiatives with enterprise governance, privacy, and compliance expectations.

Qualifications

Required

• Master’s or Ph.D. in Computer Science, Data Science, Engineering, Statistics, or related field.
• 7+ years of experience in data science and applied machine learning.
• 3+ years implementing and deploying machine learning or AI systems in production environments.
• 1+ year of hands-on agentic AI development using frameworks such as LangGraph, LlamaIndex, or CrewAI.
• Experience working with patient-level data and feature engineering
• Experience building recommender systems or related ML approaches.
• Proficiency in Python, ML frameworks (PyTorch, Scikit-learn, MLflow), and data tools (Spark, SQL).
• Demonstrated ability to work collaboratively across scientific, technical, and business teams.
• Strong communication skills with the ability to convey complex concepts clearly.
• Experience in Healthcare or Life Sciences.

Preferred

• Familiarity with Databricks and modern cloud-based ML development.
• Experience deploying Agents to production environments.
• Proven track record of building AI solutions in Healthcare and Life Sciences.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $163,000 - $200,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.