Senior Director/Executive Director, DMPK

JOB SUMMARY Iambic Therapeutics is seeking an experienced DMPK leader to lead our Drug Metabolism & Pharmacokinetics function. Reporting to senior leadership, you will define the scientific strategy for DMPK from early discovery through IND-enabling studies. You will collaborate with internal and external partners to plan and execute DMPK studies. This is a high-impact, hands-on leadership role for someone who thrives at the intersection of rigorous science and strategic drug development. KEY RESPONSIBILITIES - Lead and manage all DMPK strategy and execution across Iambic's discovery programs, setting clear goals and ensuring alignment with cross-functional program teams. - Design and oversee non-clinical ADME/PK studies and PK/PD modeling to enable candidate selection and accelerate IND filings. - Serve as the internal DMPK subject matter expert, partnering with medicinal chemistry, biology, toxicology, and clinical teams to interpret data and guide program decisions. - Build and manage a high-performing network of CRO partners and academic collaborators to supplement internal capabilities. - Lead preparation and review of DMPK sections for regulatory submissions including INDs and NDAs; interact with health authorities as needed. - Champion compliance with ICH guidelines, FDA regulations, and industry best practices across all DMPK activities. - Contribute scientific expertise to business development, due diligence, and partnership evaluations. - Stay at the forefront of emerging DMPK science, technologies, and regulatory trends to continuously strengthen the function. QUALIFICATIONS - PhD in Pharmacokinetics, Pharmaceutical Sciences, or closely related discipline or PharmD - 12+ years of experience in the pharmaceutical or biotechnology industry, with at least 3 years of leadership experience in DMPK. - Proven experience in designing, conducting, and interpreting DMPK studies supporting small molecule oncology programs. - Experience with regulatory submissions is required. - Expertise in regulatory requirements and industry standards for DMPK studies (ICH guidelines, FDA regulations etc.). - Excellent communication, collaboration, and leadership skills. - Ability to work independently and manage multiple priorities in a fast-paced, team-oriented environment. ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.