Senior Computational Biologist

<meta><h1 style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;line-height:1.6;font-size:18pt;font-weight:600;letter-spacing:1px;margin-top:24px;margin-bottom:4px;padding-left:0px;"><u><b><strong style="color:rgb(0,0,0);text-decoration:underline;white-space:pre-wrap;">About the Role:</strong></b></u></h1><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Your mission as a Computational Biologist at Gordian is to measure the impact of single-cell perturbations on transcriptomic state, and use those signals to predict changes in physiological state under therapeutic conditions. </strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">You’ll focus on cardio-renal-metabolic indications and relevant tissues (heart, kidney, adipose, liver, etc.), partnering closely with disease-area experts and experimental teams to translate screen results into clear, testable biological hypotheses.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Working collaboratively with other computational members, you will guide key analytical decisions that shape how screens are designed, QC’d, interpreted, and ultimately used to help select hits for validation. This includes developing and applying robust approaches for handling heterogeneous contexts, confounders, and controls, communicating conclusions with high interpretability and generalizability, and ensuring the right context and outputs flow back to the single-cell team and disease experts to continuously improve data generation and troubleshooting.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">You’ll also integrate internal screen data with relevant public genomics resources to connect perturbation-driven molecular changes to in vivo physiology, identifying high-confidence features that capture desirable phenotypes, and build a prioritized set of candidate targets for future screens on the basis of those predictions. Over time, you’ll help establish and iterate on selection criteria for validation that improves screening efficiency and translatability across programs.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">In your first month</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">, you’ll become fluent in our in-house pipelines and workflows and independently propose analysis tasks supporting our Obesity and Heart Failure programs, starting with resource gathering and structured data exploration.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">By three months</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">, you’ll make significant contributions to feature development and/or validation, including evaluating alternative analytical approaches with appropriate use of controls, statistical testing, and an emphasis on interpretability tied to mechanism-of-action validation.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">At six months</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">, you’ll help define strong positive and negative controls (indicators) for these screens, partner independently with disease experts on forward screen planning, and use existing validation comparisons to assess predictive power, proposing concrete improvements to analysis methodologies along the way.</span></p><h1 style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;line-height:1.6;font-size:18pt;font-weight:600;letter-spacing:1px;margin-top:24px;margin-bottom:4px;text-align:justify;padding-left:0px;"><u><b><strong style="color:rgb(0,0,0);font-size:18pt;text-decoration:underline;white-space:pre-wrap;">And You:</strong></b></u></h1><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">PhD in Bioinformatics, Computational Biology, or a related quantitative field.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Recognized domain expert in computational biology with at least 2+ years of hands-on experience analyzing single-cell transcriptomic data (industry and/or postdoctoral) across different biological contexts, and a proven track record of productivity with </span><i><b><strong style="color:rgb(0,0,0);font-size:12pt;font-style:italic;white-space:pre-wrap;">at least one </strong></b></i><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">peer-reviewed publication or pre-print that includes a major contribution as a co-author</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Proactive and passionate about assessing new developments in the field including and not limited to single cell and functional genomics, human genetics etc., using appropriate tools for analysis applications&nbsp; in each case.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Strong proficiency in both Python and R for single-cell analysis (for example, Scanpy and Seurat) and general data analysis, with the ability to move fluidly between ecosystems and experience working on high performance clusters (AWS, GCL)</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Working knowledge of NGS workflows and common file formats (including FASTQ and BAM), with the ability to adapt or modify pipelines and communicate clear implementation requirements to infrastructure partners.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Strong statistical foundations and judgment around controls, confounders, and interpretability, plus the ability to communicate results clearly through honest, high-signal visualizations and concise summaries.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Applies in-depth knowledge to practical problem solving with a result-driven mindset</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">High ownership, self-motivation and strong cross-functional communication skills, with a track record of partnering effectively with experimental teams and domain experts in a fast-paced, ambiguous environment.</span></li></ul><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><u><span style="color:rgb(0,0,0);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">Additional valuable skills if you have them</span></u></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience with pooled perturbation and screening data (for example, CRISPR or barcode-driven screens) and single-cell perturbation analysis methods.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Prior work in cardio-renal-metabolic biology and relevant tissues (heart, kidney, adipose, liver), either directly or through close collaboration with disease experts.</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience integrating vast public genomics resources with internal data and building scalable workflows for large datasets (HPC and/or cloud).</span></li><li style="color:rgb(0,0,0);font-size:12pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience with preclinical models for validation with functional readouts (e.g. in human explants, organoids, etc)</span></li></ul><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><u><b><strong style="color:rgb(0,0,0);font-size:18pt;text-decoration:underline;white-space:pre-wrap;">The Details:</strong></b></u></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">G</span><span style="color:rgb(24,151,109);font-size:12pt;white-space:pre-wrap;">o</span><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">rdian aims to provide everything you need to thrive. Beyond or community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco, and this position would hyrbid/onsite. </span></p> <meta><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><i><em style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Are you ready to own the analysis, predictive modeling and interpretation of large-scale perturbation single-cell transcriptomic screens, turning high-dimensional, complex gene expression state changes into clear biological conclusions that drive therapeutic decisions in cardio-renal-metabolic disease?</em></i></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><i><em style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Large-scale transcriptomic data is at the heart of Gordian’s discovery efforts, and the company will succeed based on our ability to accurately predict physiological changes in disease using single cell gene expression as a readout. In this role, you’ll help ensure our screening and validation decisions are grounded in rigorous, transparent and state-of-the-art analyses, enabling us to confidently prioritize the best targets and interventions.</em></i></p><h1 style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;line-height:1.6;font-size:20pt;font-weight:600;letter-spacing:1px;margin-top:24px;margin-bottom:4px;padding-left:0px;"><u><span style="color:rgb(0,0,0);font-size:18pt;text-decoration:underline;white-space:pre-wrap;">The Destination:</span></u></h1><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Gordian Biotechnology is a therapeutics company whose mission is to cure age-related disease and wake up every morning more capable than the day before.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Traditional </span><i><em style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">ex vivo</em></i><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;"> screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">To address this problem, Gordian’s platform is the first and only to enable pooled </span><i><em style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">in vivo</em></i><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;"> tests at scale, across different species of diseased animals reflecting patient profiles. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to rapidly prioritize targets and interventions with a clear path toward development (more info on our </span><a href="http://www.gordian.bio" target="_blank" class="css-173makr-linkStyle" style="color:rgb(30,74,169);cursor:pointer;"><u><span style="color:rgb(17,85,204);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">website</span></u></a><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">).&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">We are running this discovery engine to ensure an abundance of therapeutic hypotheses can be tested for complex diseases, eventually mapping out the effects of every druggable target across many diseases, and advancing programs both internally and through collaborations with external partners. By working across related sets of indications, we can identify medicines with impacts on age-related multimorbidity.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><u><b><strong style="color:rgb(0,0,0);font-size:16pt;text-decoration:underline;white-space:pre-wrap;">The Journey:</strong></b></u></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Team</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;"> – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Extraordinary </strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">– Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Like any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. We have an unlimited vacation policy, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">If this environment sounds appealing, help us bring it to life. We are at an exciting inflection point: applying our technology to create comprehensive atlases of therapeutic targets across multiple diseases, partnering for financial and intellectual support, and translating these insights into new medicines. We want both your ability and personality along for the ride. Our culture is a source of great pride; it represents both who we are and who we wish to be.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:12pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">You can dive deeper here: </span><a href="https://www.gordian.bio/culture/" target="_blank" class="css-173makr-linkStyle" style="color:rgb(30,74,169);cursor:pointer;"><u><span style="color:rgb(17,85,204);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">https://www.gordian.bio/culture/</span></u></a></p>