Senior Analog/Mixed-Signal Hardware Engineer, Single-Molecule Sensing Instrumentation

Why This Role

Nanopore sensing is one of the most demanding analog measurement problems in life sciences: picoamp-scale currents, wide bandwidth, and very low noise, ideally across many channels in parallel. You will own the electronics that make that measurement possible, from the analog front end through the board-level system, and see your designs used directly by the scientists who depend on them.

About Tilde (FL110)

Tilde Bio, Inc. (FL110), a Flagship Pioneering company, is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. Our goal is to create programmable biological measurement systems capable of extracting rich molecular information from single-molecule interactions.

We believe nanopores generate a high-dimensional measurement of molecular identity and behavior that remains largely untapped. Unlocking that information requires new computational approaches — ones that don't yet exist — built by people who are comfortable working at the edge of what's known. At Tilde, you will work alongside scientists and engineers from diverse disciplines to help define how a new generation of biological sensing systems extract meaning from the physical world.

Tilde is backed by Flagship Pioneering, which brings the long-term vision and resources needed to build platforms that don't fit neatly into existing categories.

Position Summary

We are seeking a highly motivated and experienced Senior Electrical Engineer with deep expertise in low-noise analog and mixed-signal design and printed circuit board (PCB) design and development to join our multidisciplinary engineering team. This individual will play a critical role in the design, layout, integration, and validation of complex PCBs that support our next-generation biological sensing platform.

The ideal candidate will have strong experience in low-noise mixed-signal PCB design, signal integrity, power integrity, and system-level integration. This role requires close collaboration with firmware, mechanical, bioengineering, and systems teams to deliver robust, manufacturable, and high-performance hardware solutions from concept through production.

About the Role

• Reports to: VP of Technology and Development
• Team: 4 Engineer plus consultants
• Stage: Full product cycle but starting with prototyping
• First-year focus: Prototype sensors

Key Responsibilities

• Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems, including low-noise, picoamp-level sensing electronics.
• Architect low-noise, mixed-signal circuit designs including analog front ends, power management, data acquisition, and embedded processing systems.
• Collaborate with SW and HW engineers as well as external vendors to ensure seamless hardware–software integration and instrument development.
• Develop and maintain comprehensive documentation including schematics, layout files, validation reports, and specifications.
• Drive design reviews, design for manufacturability (DFM), and design for testability (DFT) best practices.
• Contribute to intellectual property generation and technical strategy discussions.

Basic Qualifications

• B.S., M.S., or Ph.D. in Electrical Engineering or a related field.
• 5+ years of industry experience in PCB design and hardware development.
• Demonstrated expertise in multilayer PCB design for low-noise analog and mixed-signal systems.
• Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
• Hands-on experience with board bring-up, debugging, and lab instrumentation (oscilloscopes, logic analyzers, spectrum analyzers).
• Experience taking products from prototype through manufacturing.

Nice-to-Haves

• Experience with low-noise electrophysiology, patch-clamp, or nanopore instrumentation.
• Experience with high-speed interfaces (e.g., USB, Ethernet, PCIe, DDR, SPI, I2C).
• Experience designing electronics for scientific instrumentation, medical devices, or life sciences platforms.
• Familiarity with FPGA-based systems and embedded processors.
• Experience with high-density interconnect (HDI) design and fine-pitch components.
• Knowledge of regulatory compliance standards (e.g., CE, FCC, IEC).
• Experience working in early-stage or startup environments.

About Flagship Pioneering

Flagship Pioneering is a bio-platform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $108,000 - $176,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL110 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL110's good faith estimate as of the date of publication and may be modified in the future.