Description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a Scientist or Senior Scientist to lead the molecular biology function within our Cell Sciences team. This role serves as the molecular biology subject matter expert supporting cell line development, owning vector and construct design strategy and the nucleic acid analytics that underpin clone characterization. It is well suited to a scientist who combines deep hands-on molecular biology expertise with the judgment to design experimental strategy independently and the interest in developing junior scientific staff.

This is a full-time onsite position in Bothell, WA.

Responsibilities

Lead the design and execution of molecular biology strategies supporting cell line development programs, including expression vector design, construct generation, and nucleic acid analytics for bi-specific and multi-specific antibodies and ADCs.
Design mammalian expression vectors and cloning strategies for complex multi-chain and multi-specific antibody formats; evaluate and optimize vector architecture, regulatory elements, and selection systems to improve expression and product quality.
Develop, qualify, and troubleshoot digital droplet PCR (ddPCR) assays for absolute nucleic acid quantification, including transgene copy number determination, and gene expression analysis in support of clone characterization and cell line stability assessment.
Perform and oversee routine and high-throughput molecular biology workflows, including library preparation, PCR, restriction endonuclease digestion, Gibson Assembly, Golden Gate Assembly, bacterial transformations, and plasmid purification.
Serve as the molecular biology subject matter expert to the Cell Line Development group, partnering with cell culture, protein sciences, and analytical teams to align construct design with expression, productivity, and developability objectives.
Supervise, train, and develop 1–2 Research Associates; set experimental priorities, review data for scientific rigor, and ensure adherence to documentation standards.
Evaluate and implement new molecular biology technologies, laboratory automation, and next-generation sequencing approaches to improve throughput, data quality, and program timelines.
Analyze, interpret, and present experimental data to cross-functional teams and senior leadership; author technical reports, protocols, and sections of IND-enabling and regulatory documentation.
Maintain detailed and reproducible records of experimental procedures and results in electronic lab notebooks.
Manage multiple projects and shifting priorities simultaneously in a fast-paced, milestone-driven environment.

Qualifications

Ph.D. in Molecular Biology, Cell Biology, Biochemistry, or a related field.
Demonstrated expertise in molecular cloning and construct design, including PCR, Gibson Assembly, Golden Gate Assembly, restriction endonuclease digestion, bacterial transformation, and plasmid preparation.
Hands-on experience developing and executing digital droplet PCR (ddPCR) and/or quantitative PCR (qPCR) assays, including assay design, optimization, and data analysis.
Experience designing mammalian expression vectors for therapeutic proteins; experience with multi-specific antibody or ADC formats is strongly preferred.
Working knowledge of cell line development workflows and an understanding of how construct design influences expression, productivity, and clone stability.
Experience with next-generation sequencing workflows and data interpretation is a plus.
Liquid handler and laboratory automation experience is a plus.
Prior experience mentoring, training, or supervising junior scientific staff.
Excellent written and verbal communication skills, with a track record of presenting data to cross-functional audiences.
Strong organizational skills and attention to detail, with the ability to work both independently and as part of a collaborative team.
Comfortable working in a dynamic environment with shifting priorities.

Scientist / Senior Scientist, Molecular Biology

Description

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