Scientist, Pharmacometrician - all genders (limited for 2 years)

<p><b><i>About the job</i></b></p><p></p><p>Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&amp;D, you’ll drive breakthroughs that could turn the impossible into possible for millions.</p><p>Ready to shape the future of medicine through cutting-edge pharmacometrics?</p><p>Join Sanofi&#39;s Pharmacometrics Research Group Germany and accelerate drug discovery from hit identification to translation for first-in-human studies!</p><p></p><p><b>About Sanofi: </b></p><p>We’re an R&amp;D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.</p><p></p><p><span>Key Responsibilities</span></p><p><b><span>Modeling &amp; Simulation Excellence</span></b></p><p><span>Support early and late research project teams with state-of-the-art quantitative approaches enabling data-based decision making. Among others your activities will include: </span></p><p><span><span><span>        </span></span></span><span>Conduct comprehensive <b>early feasibility analyses (EFA)</b> to assess compound viability and guide project progression decisions</span></p><p><span><span><span>        </span></span></span><span>Perform <b>non-compartmental analysis (NCA)</b> and <b>empirical pharmacokinetic/pharmacodynamic (PK/PD) modeling</b> to characterize drug exposure-response relationships and impact in vivo study designs</span></p><p><span><span><span>        </span></span></span><span>Develop and validate <b>population pharmacokinetic (popPK) models</b> using advanced mixed-effects modeling and <b>physiologically-based pharmacokinetic (PBPK) modeling</b> approaches</span></p><p><span><span><span>        </span></span></span><span>Apply <b>translational modeling approaches</b> to bridge preclinical and clinical PK/PD data, establish <b>in vitro in vivo correlations (IVIVC)</b>, conduct and evaluate <b>allometric scaling</b> methodologies for cross-species extrapolation to predict human pharmacokinetics</span></p><p><span> </span></p><p><b><span>Advanced Analytics &amp; Innovation</span></b></p><p><span><span><span>        </span></span></span><span>Apply and integrate innovative <b>machine learning methods</b> and <b>descriptive statistics</b> to extract insights from complex datasets</span></p><p><span><span><span>        </span></span></span><span>Develop predictive and descriptive models using <b>R, Python, and Julia</b> programming languages</span></p><p><span><span><span>        </span></span></span><span>Support automated workflows and visualization tools to enhance modeling efficiency</span></p><p><span> </span></p><p><b><span>Project Leadership &amp; Collaboration</span></b></p><p><span><span><span>        </span></span></span><span>Serve as the pharmacometrics representative in cross-functional project teams</span></p><p><span><span><span>        </span></span></span><span>Provide strategic modeling guidance from target identification through clinical candidate selection</span></p><p><span><span><span>        </span></span></span><span>Support <b>first-in-human (FIH) dose selection</b> and clinical study design optimization</span></p><p><span><span><span>        </span></span></span><span>Collaborate with in vitro, in vivo, toxicology, and biostatistics groups</span></p><p><span><span><span>        </span></span></span><span>Contribute to regulatory submissions and interact with health authorities when required</span></p><p><span> </span></p><p><b><span>Scientific Communication &amp; Development</span></b></p><p><span><span><span>        </span></span></span><span>Present findings at internal project meetings and external scientific conferences</span></p><p><span><span><span>        </span></span></span><span>Publish research in peer-reviewed journals to advance the field of pharmacometrics</span></p><p><span><span><span>        </span></span></span><span>Prepare comprehensive modeling reports and regulatory documents</span></p><p><span><span><span>        </span></span></span><span>Opportunities to mentor junior scientists and contribute to team capability building</span></p><p><span>Required Qualifications &amp; Experience</span></p><p><b><span>Education &amp; Experience</span></b></p><p><span><span><span>        </span></span></span><b><span>PhD</span></b><span> in pharmacometrics, pharmaceutical sciences, applied mathematics, systems biology, bioengineering, bioinformatics, or related quantitative field</span></p><p><span><span><span>        </span></span></span><span>Experience in pharmaceutical industry, regulatory agencies, or academia is desirable</span></p><p><span><span><span>        </span></span></span><span>Track record of applying PK/PD modeling &amp; simulation in drug development context</span></p><p><span> </span></p><p><b><span>Technical Expertise</span></b></p><p><b><span>Proficiency</span></b><span> in pharmacometrics software tools and programing languages (<b>R, python,</b> <b>Julia, Pumas,</b> <b>OSP-suite (PK-Sim/MoBi), SimCyp, </b>NONMEM, Monolix)</span></p><p><span><span><span>        </span></span></span><b><span>Solid understanding</span></b><span> of ADME principles across multiple modalities (small molecules, biologics (antibodies, nanobodies), RNA therapeutics, PROTACs)</span></p><p><span><span><span>        </span></span></span><b><span>Expertise</span></b><span> in machine learning applications in drug development beneficial</span></p><p><span><span><span>        </span></span></span><b><span>Experience</span></b><span> with real-world preclinical and clinical PK/PD data analysis</span></p><p><span><span><span>        </span></span></span><b><span>Knowledge</span></b><span> of regulatory guidelines and industry best practices</span></p><p><b><span> </span></b></p><p><b><span>Core Competencies</span></b></p><p><span><span><span>        </span></span></span><b><span>Strategic thinking</span></b><span> with ability to identify opportunities for model-informed drug development</span></p><p><span><span><span>        </span></span></span><b><span>Problem-solving skills</span></b><span> to address complex pharmacological questions</span></p><p><span><span><span>        </span></span></span><b><span>Communication excellence</span></b><span> to convey technical concepts to diverse audiences</span></p><p><span><span><span>        </span></span></span><b><span>Collaborative mindset</span></b><span> for working in matrix organizations and international teams</span></p><p><span><span><span>        </span></span></span><b><span>Scientific rigor</span></b><span> in model development, validation, and documentation</span></p><p><b><span> </span></b></p><p><b><span>Language Requirements</span></b></p><p><span><span><span>        </span></span>Excellent written and verbal communication skills in English</span></p><p><span><span><span>        </span></span></span><span>German language skills are advantageous but not required</span></p><p></p><p>Why choose us?</p><ul><li>Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. </li><li>Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. </li><li>Help improve the lives of millions of people globally by making drug development quicker and more effective. </li><li>Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs. </li><li>Benefit from a well-thought-out benefits package that rewards your contribution and commitment.</li></ul><p></p><p>#LI-Onsite</p><p>#Pharmacometrics</p><p>#DrugDevelopment</p><p>#PKPD</p><p>#Modeling</p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;sanofi&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7227338801126264833" target="_blank"><span>#Sanofi</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;sanoficareers&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7108450102200938498" target="_blank"><span>#SanofiCareers</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;discoverextraordinary&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7227578032092315648" target="_blank"><span>#DiscoverExtraordinary</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;sanofistories&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7209134303526436865" target="_blank"><span>#SanofiStories</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;weneversettle&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7228792518958551040" target="_blank"><span>#WeNeverSettle</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;teamsanofi&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7228516537110835200" target="_blank"><span>#TeamSanofi</span></a></p><p><a href="https://www.linkedin.com/feed/hashtag/?keywords&#61;ignitingpotential&amp;highlightedUpdateUrns&#61;urn%3Ali%3Aactivity%3A7224858521010384896" target="_blank"><span>#IgnitingPotential</span></a></p><p style="text-align:inherit"></p><p style="text-align:inherit"></p><h1>Pursue <i>progress</i>, discover <i>extraordinary</i></h1><p>Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.</p><p></p><p>At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.</p><p></p><p>Watch our <a href="https://www.youtube.com/watch?v&#61;SkpDBZ-CJKw&amp;t&#61;67s" target="_blank">ALL IN video</a> and check out our Diversity Equity and Inclusion actions at <a href="https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness" target="_blank">sanofi.com</a>!</p>