Scientist, Molecular Assays

Legend Biotech is seeking a Scientist, Molecular Assays as part of the Bioanalytical Sciences team based in Somerset, NJ.

Role Overview

We are seeking a highly motivated scientist to join our Bioanalytical Sciences team. This position will support the development, execution, and optimization of molecular assays for clinical, translational, and preclinical programs. The successful candidate will contribute to a broad range of molecular biology activities, with primary responsibilities focused on quantitative PCR (qPCR), digital droplet PCR (ddPCR), and next-generation sequencing (NGS), including single-cell sequencing workflows.

The ideal candidate will have hands-on experience with molecular biology techniques, strong laboratory execution skills, and exceptional attention to detail. Experience with qPCR, ddPCR, nucleic acid extraction, NGS library preparation, and biological sample processing is highly desirable. This role offers an excellent opportunity for an early-career scientist to work in a fast-paced biotechnology environment supporting innovative cell and gene therapy programs while collaborating with multidisciplinary teams across research and development.

Key Responsibilities

• Perform molecular biology experiments supporting clinical, translational, and preclinical research programs.
• Execute qPCR and ddPCR assays for gene expression analysis, biomarker quantification, transgene detection, vector copy number determination, and biodistribution studies.
• Support development, optimization, qualification, transfer, and troubleshooting of molecular assays.
• Perform nucleic acid extraction, quantification, and quality assessment from blood, tissue, cell culture, and other biological samples.
• Prepare samples and perform library preparation for next-generation sequencing (NGS) applications, including single-cell RNA sequencing (scRNA-seq).
• Operate and maintain molecular biology instrumentation, including qPCR, ddPCR, and NGS-related platforms.
• Analyze experimental data, ensure data quality, maintain accurate laboratory documentation, and assist in the preparation of protocols, SOPs, technical reports, and assay-related documents.
• Process, track, and manage biological samples using LIMS and ELN systems while ensuring sample integrity and traceability.
• Support laboratory operations, including inventory management, sample shipments, equipment maintenance, and laboratory organization.
• Contribute to the continuous improvement of laboratory workflows, assay performance, and operational efficiency.

Requirements

• M.S. in Life Sciences, Molecular Biology, Biochemistry, or a related field with 8+ years of relevant experience, or Ph.D. in a related scientific discipline with 3+ years of relevant experience.
• Hands-on experience with molecular biology techniques, including nucleic acid extraction, qPCR, RT-qPCR, and/or ddPCR.
• Experience with NGS workflows and library preparation; single-cell sequencing experience is a plus.
• Familiarity with assay development, data analysis, and biological sample processing.
• Experience in cell and gene therapy, immunology, oncology, or regulated laboratory environments is desirable.
• Strong attention to detail, organization, and documentation skills.
• Excellent analytical, problem-solving, and communication skills.
• Ability to work independently and collaboratively in a fast-paced laboratory environment.
• Commitment to data quality, laboratory safety, and continuous learning.
• Work in a clinical, research, pharmaceutical, or diagnostic laboratory.
• May require standing for extended periods and lifting up to 25 pounds.
• Use of personal protective equipment (PPE) is required.
• Involve handling biological specimens and hazardous materials following safety guidelines.
  
  

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