Scientist, In Vivo CAR-T Pipeline

Legend Biotech is seeking a Scientist, In Vivo CAR-T Pipeline as part of the Research and Development team based in Philadelphia, PA.

Role Overview

Legend Biotech is a global leader in the development of innovative cell-based therapies. We are seeking a highly motivated Scientist to join our growing in vivo CAR-T development team. This role provides the opportunity to make a direct scientific impact by advancing our in vivo CAR-T platform from early discovery through preclinical development.

The successful candidate will bring deep technical expertise in cell&gene therapy, along with a strong foundation in immunology and virology. You will work in a highly collaborative environment alongside research and early development teams to translate novel scientific concepts into robust therapeutic candidates. This role requires scientific rigor, hands-on execution, intellectual curiosity, and the ability to thrive in a fast-paced research setting.

This is a fully onsite, lab-based position located in Philadelphia, PA.

Key Responsibilities

• Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs.
• Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety.
• Develop, optimize, and troubleshoot experimental assays, including:
  • Cell line engineering
  • Cell-based functional and cytotoxicity assays
  • ELISA and PCR-based assays
  • High-throughput binder screening
  • Viral vector packaging and titration
  • Analyze and interpret complex datasets and maintain accurate experimental documentation.
  • Prepare clear, high-quality reports and presentations and communicate findings to internal research and cross-functional teams.
    

Requirements

• PhD in Immunology, Cell Biology, Molecular
• OR Master’s degree with 3–6+ years of relevant experience
• Hands-on experience in immunology, cell therapy, gene therapy, or related fields
• Experience with viral vector systems (especially lentivirus) is highly preferred
• Industry or postdoctoral experience is a plus

 

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