Scientist II, Process Chemistry

The Opportunity:

We are seeking a gifted experimentalist to join our team as a laboratory-based process chemist to own development workstreams for a small-molecule drug substance. You will independently design and execute experiments, solve complex chemistry problems, and develop robust processes suitable for scale-up and technology transfer. This is a hands-on individual contributor role with responsibility for scientific recommendations and delivery of assigned development objectives.

• Own the development of reactions, process steps, or development workstreams, setting experimental approaches and coordinating work to meet agreed project objectives.

• Design and execute experiments to evaluate alternative routes and optimize reactions, workup, isolation, and crystallization conditions.

• Investigate complex reaction behavior and impurity formation using mechanistic reasoning, experimental design, comparison of analytical data, and understanding relevant scientific literature.

• Develop robust processes by defining parameter sensitivity, reproducibility, impurity control, solubility limits, and other practical requirements for manufacturing.

• Plan and execute laboratory studies and translate results into recommendations for process implementation at large-scale.

• Prepare technology transfer procedures and work with external contract development and manufacturing organizations (CDMOs) to resolve implementation issues.

• Author process development reports and technical content supporting regulatory documentation; maintain complete electronic laboratory records.

• Provide scientific guidance to research associates, present recommendations to project teams, and identify and address laboratory and process safety risks.

Required Skills, Experience and Education:

• PhD in organic chemistry and at least 2 years of related experience, which may include postdoctoral research.

• Demonstrated ability to independently design and execute process development studies and solve complex synthetic chemistry problems.

• Strong hands-on skills in multistep synthesis, reaction optimization, isolation, and characterization using NMR, chromatography, and mass spectrometry.

• Ability to connect experimental results with process robustness, scale-up considerations, and project objectives.

• Experience taking responsibility for a defined scientific workstream and providing technical guidance to colleagues.

• Clear scientific writing, effective collaboration, and proficiency with electronic laboratory notebooks, data analysis tools, and ChemDraw.

Preferred Skills:

• Industry experience in pharmaceutical process development, laboratory scale-up, crystallization, or technology transfer to CDMOs.

• Experience with design of experiments, automated laboratory reactors, cGMP manufacturing, or drug substance regulatory documentation.

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