Scientist II, Computational Biology & AI

<p style="text-align:left"><u><b>Job Description:</b></u></p><p style="text-align:inherit"></p><p><b>Company Overview</b></p><p>Since its inception over a decade ago, CRISPR <span><span><span><span><span><span><span><span><span><span><span><span><span>Therapeutics has</span></span></span></span></span></span></span></span></span></span></span></span></span> transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR <span><span><span><span><span><span><span><span><span><span><span><span><span>Therapeutics has</span></span></span></span></span></span></span></span></span></span></span></span></span> established strategic partnerships with leading companies including Vertex <span><span><span><span><span><span><span><span><span><span><span><span><span>Pharmaceuticals. CRISPR</span></span></span></span></span></span></span></span></span></span></span></span></span> Therapeutics AG is headquartered in Zug, Switzerland, with its <span><span><span><span><span><span><span><span><span><span><span><span><span>wholly-owned U.S. subsidiary, CRISPR</span></span></span></span></span></span></span></span></span></span></span></span></span> Therapeutics, Inc., and R&amp;D operations based in Boston, <span><span><span><span><span><span><span><span><span><span><span><span><span>Massachusetts and San</span></span></span></span></span></span></span></span></span></span></span></span></span> Francisco, California.</p><p></p><p><b>Position <span>Summary</span></b></p><p>We are seeking a highly motivated and talented Computational Biology &amp; AI Scientist to grow our CRISPR-X and Genomics teams at CRISPR Therapeutics. The scientist in this role will leverage computational genomics and machine learning to advance next-generation in vivo therapies for gene correction and gene insertion into the clinic, including designing novel CRISPR proteins and characterizing gene-editing safety. The successful candidate will own technical strategy, collaborate closely with cross-functional research groups, and deliver contributions that directly impact patients with serious diseases. The position requires outstanding skills in computational biology, ML/AI, and genomics; a high degree of scientific rigor and attention to detail; and a passion for creating new medicines for patients.</p><p></p><p><b>Responsibilities</b></p><ul><li><span>Lead computational genomics and ML/AI activities in a cross-functional drug development setting</span></li><li><span>Generate and test hypotheses on genome-scale data using analytical, statistical, and machine learning methods</span></li><li>Perform computational analyses to thoroughly characterize off-target gene editing to ensure the safety of CRISPR-based drug products</li><li>Apply and develop ML/AI tools to engineer and optimize CRISPR and other gene-editing modalities for improved efficacy and specificity, working in iterative design-test cycles with a world-class team of cellular and molecular biologists</li><li><span>Develop and maintain reproducible computational and ML/AI pipelines for genomic and molecular data analysis</span></li><li><span>Author scientifically rigorous research reports to support IND submissions and other regulatory filings</span></li><li><span>Present scientific findings to a broad range of audiences, including senior leadership, to help inform decision-making for therapeutic programs </span></li><li><span>Dissect published literature and cutting-edge developments in the ML/AI space to find novel solutions for in vivo gene-editing problems </span></li></ul><p></p><p><b>Minimum Qualifications</b></p><ul><li>Ph.D. in computational biology, bioinformatics, genomics, machine learning, computer science, or a related field</li><li>At least 2 years of industry or postdoctoral experience characterizing on-/off-target editing, optimizing gene-editing modalities, or developing AI/ML-driven approaches for therapeutic protein design</li><li>Demonstrated record of developing computational pipelines to analyze high-throughput DNA sequencing data, with proficiency in common bioinformatics tools (e.g., BWA, SAMtools, GATK, IGV)</li><li>Proven ability to develop and apply machine learning and/or AI methods to solve challenging problems in the biological domain</li><li>Proficiency with Python is essential; familiarity with additional languages such as C&#43;&#43;, R, or Julia is a plus</li><li>Ability to work independently and effectively in a matrix environment, prioritize and manage multiple tasks simultaneously, and balance competing priorities</li><li>Excellent writing, reviewing, and presentation skills</li><li>A high degree of scientific rigor, accuracy, and attention to detail</li></ul><p><br /><b>Preferred Qualifications</b></p><ul><li>Experience applying ML/AI tools for protein structure prediction (e.g., AlphaFold), de novo protein design (e.g., RFdiffusion), and/or biomolecular sequence modeling (e.g., ESM, Evo)</li><li>Proficiency with statistical and machine learning methods, including familiarity with ML frameworks (e.g., PyTorch, TensorFlow, or scikit-learn)</li><li>Familiarity with sequencing platforms (Illumina, PacBio, Oxford Nanopore, 10x Genomics) and NGS library preparation methods</li><li>Demonstrated record of authoring research reports to support regulatory filings (e.g., IND modules, Investigator&#39;s Brochures)</li><li>Proficiency in managing and analyzing large-scale genomic data in a Linux and/or cloud environment (e.g., AWS)<br /> </li></ul><p><b><span>Competencies</span></b></p><ul><li>Collaborative – Openness, One Team</li><li>Undaunted – Fearless, Can-do attitude</li><li>Results Orientation – Delivering progress toward our mission. A sense of urgency in solving problems.</li><li>Entrepreneurial Spirit – Proactive. Ownership mindset.</li></ul><p></p><p><span>CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.</span></p><p></p><p>Senior Clinical Scientist: <span>Base pay range of $140,000 to $150,000&#43; bonus, equity and benefits</span></p><p><span>The range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.</span></p><p></p><p><span>CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person&#39;s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. </span></p><p></p><p><span>To view our Privacy Statement, please click the following link:</span> <a href="http://www.crisprtx.com/about-us/privacy-policy" target="_blank">http://www.crisprtx.com/about-us/privacy-policy</a></p>