Scientist II, Cancer Pharmacology, Translational Research

<p>Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.</p> <p><strong>The Opportunity:</strong></p> <p>As a Scientist II in the Translational Research team, within the Biology Department, you will:</p> <ul> <li> <p>As a member of a cross-functional quantitative modeling group, collaborate with team members to develop, validate and refine physiologically-based PK (PBPK), quantitative systems pharmacology (QSP), and semi-mechanistic PK/PD models to support discovery and development-phase projects.</p> </li> <li> <p>Seek and apply innovative modeling approaches to understand tumor resistance to RAS(ON) inhibitors and build in silico models, propose mechanistic in vitro and in vivo experiments to test model assumptions and structure.</p> </li> <li> <p>Design and oversee in vivo and ex vivo studies (internally and via CROs), develop and maintain high-quality protocols and documentation, and present results at internal forums and scientific conferences.</p> </li> </ul> <p><strong>Required Skills, Experience and Education:</strong></p> <ul> <li> <p>Ph.D. in pharmacology or cancer biology, or a quantitative discipline (pharmaceutical sciences, mathematics, systems pharmacology, computational biology, etc.) with direct relevance to drug development.</p> </li> <li> <p>2+ years of relevant postdoc or industry experience in cancer drug discovery and development.</p> </li> <li> <p>Demonstrated experience in <em>in vivo</em> experiments with oncology disease models.</p> </li> <li> <p>Solid PK/PD knowledge and prior experience with PK/PD data collection and analysis.</p> </li> <li> <p>A strong theoretical understanding of the core concepts, assumptions, and limitations associated with PK/PD mathematical modeling</p> </li> <li> <p>Rigorous, quantitative and detail-oriented with proven excellence in experimental design, data analysis, data management, and presentation.</p> </li> </ul> <ul> <li> <p>Excellent written and verbal communication skills. Able to effectively communicate modeling assumptions, limitations, and simulation results to non-specialist and specialist audiences.</p> </li> <li> <p>Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.</p> </li> <li> <p>Thrives in a collaborative team setting and is driven by a desire to be innovative in a dynamic and fast-paced environment.</p> </li> </ul> <p><strong>Preferred Skills:</strong></p> <ul> <li> <p>An understanding of preclinical to clinical translational concepts desired.</p> </li> <li> <p>Strong track record of research productivity as evidenced by high-quality, impactful publications.</p> </li> <li> <p>Experience with development, calibration, and validation of ordinary differential equation (ODE) and non-linear mixed effect (NLME) models.</p> </li> <li> <p>Hands on experience with modeling software (Simbiology, Phoenix WinNonlin, NONMEM, etc.) and PBPK model development.<br><span style="color: rgb(255, 255, 255);">#LI-Hybrid   #LI-NE1</span></p> </li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p>The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.</p> <p>Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.</p> <p>Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.</p> <p>Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our <a href="https://www.revmed.com/ccpa-notice">CCPA Notice</a> and <a href="https://www.revmed.com/privacy-policy">Privacy Policy</a>. For additional information, please contact <a href="mailto:privacy@revmed.com">privacy@revmed.com</a>.</p></div><div class="title">Base Pay Salary Range</div><div class="pay-range"><span>$128,000</span><span class="divider">—</span><span>$160,000 USD</span></div></div></div><div class="content-conclusion"><hr> <p><em>We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.</em><br><em> </em><br><em>Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official <strong>@revmed.com</strong> email address.</em><br><em> </em><br><em>If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to <span style="color: rgb(35, 111, 161);"><strong>careers@revmed.com</strong></span> so we can share these impersonations with our IT team for tracking and awareness.</em></p> <hr> <p> </p></div>