Scientist I, Sustaining

The Position: Scientist I, Sustaining

Onsite South San Francisco, CA

We are looking for a highly motivated individual to join the Sustaining Team as a Scientist I. The individual in this position will play an integral role in designing experiments and analyzing data to support process improvements and troubleshooting activities in our production laboratory. This position requires, in collaboration with the CLIA operations, bioinformatics, R&D, and quality teams, planning and execution of technical studies aimed at improving genomics assay workflows, proactively identifying trends, and reducing supply chain related risks.  We would like you to share our commitment to teamwork and collaboration and be excited by the challenges of applying your scientific expertise to develop genomic tests that improve patient diagnosis and treatment. 

 Responsibilities:

• Plan and conduct laboratory experiments aimed at understanding failure modes (guard banding) and improving the performance of high complexity molecular diagnostic tests based on genomics - inclusive of study design, feasibility testing, optimization, data analysis, and presentation of results.
• Help to develop and author SOPs, experimental protocols, and technical reports related to experimental studies that become part of the Design History File and regulatory filings.
• Interact seamlessly with multi-disciplinary teams such as the bioinformatics, CLIA operations, R&D, and quality to implement process improvements and to identify root cause of in-service problems.
• Troubleshoot and solve technical challenges that arise during the development process and routine operations.
• Collaborate with data science and bioinformatics to implement data visualization using Tableau or other tools to proactively identify trends in the production laboratory.
• Develop new controls and enhanced procedures for reagent and instrument qualifications.
• May participate in company audits as it relates to development of LDT testing.

Who You Are

• PhD in chemistry, biochemistry, molecular biology, or a related field with 0+ years of relevant industry experience, or a MS with 2+ years of experience, or a BS with 5+ years of experience.
• Experience with various molecular platforms (g. next-generation sequencing, microarrays and/or PCR), in the context of genomic assay development in a high complexity CLIA lab.
• Keen insight into experimental design, aimed at elucidating the biological factors that influence genomic results.
• Hands-on knowledge of the biochemistry underlying multi-component molecular biology methods at the sample preparation, assay, and detection level.
• Prior experience in developing or supporting molecular, genomics assays, or laboratory developed tests is strongly preferred.  
• Goal-oriented and timeline-driven to support company Demonstrated an ability to thrive in a fast-moving environment and acknowledge that product timeliness is essential to commercial success.
• Experience working with liquid handling platforms preferred.
• Must be highly motivated team player and work well with others.
• Strong organizational, communication, and interpersonal skills.
• Excellent documentation skills including writing of technical documents.
• Prior experience in interpreting genomic data and data analysis skill required.
• Detail oriented and able to problem solve and offer potential solutions.
• Relevant industry experience working in a high complexity CLIA laboratory developing or supporting laboratory developed tests.

 

 

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