Scientist I, Peptide Drug Discovery

<p style="text-align: left;"> </p> <p class="x_MsoNormal"><strong><span data-olk-copy-source="MessageBody">Why Join Us?</span></strong></p> <p>As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.</p> <p>Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.</p> <p><strong>What’s the opportunity?</strong></p> <p><span class="TextRun SCXW53995629 BCX0" lang="EN-US" data-contrast="none"><span class="NormalTextRun SpellingErrorV2Themed SCXW53995629 BCX0">Parabilis</span><span class="NormalTextRun SCXW53995629 BCX0"> Medicines has built an in-house, high-throughput multiplexed screening platform that links Helicon discovery to rapid, decision-quality testing against challenging targets. As our pipeline expands, we are scaling capacity and improving assay robustness by standardizing </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW53995629 BCX0">workflows</span><span class="NormalTextRun SCXW53995629 BCX0"> so multiple programs can run in parallel with reproducible, high-quality outputs. We are seeking a Scientist with a chemical biology mindset and strong quantitative experimental rigor to help advance and scale this platform. In this role, you will co-own execution of multiplexed screening assays and lead efforts to improve throughput, robustness, and data quality through assay optimization, automation, and workflow standardization. Over time, you will deepen your understanding of Helicon design and use high-quality </span><span class="NormalTextRun SCXW53995629 BCX0">assay</span><span class="NormalTextRun SCXW53995629 BCX0"> data to contribute to property optimization and SAR learning. </span></span><span class="EOP SCXW53995629 BCX0" data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></p> <p><strong><span class="EOP SCXW53995629 BCX0" data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}">Responsibilities include:</span></strong></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="22" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><strong><span data-contrast="none">Own and improve multiplexed screening assays:</span></strong><span data-contrast="none"> run, optimize, and standardize assays to increase robustness, reproducibility, and throughput across multiple programs.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="22" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><strong><span data-contrast="none">Advance automation in practice:</span></strong><span data-contrast="none"> enable automation for existing assays and build new assays with automation in mind, troubleshooting and iterating workflows to achieve consistent performance.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="22" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><strong><span data-contrast="none">Build script-based tools to scale execution:</span></strong><span data-contrast="none"> develop reusable scripts and lightweight tools (Python or similar) that reduce manual steps and improve experiment setup, tracking, QC, and reporting for broad team use.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="22" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><strong><span data-contrast="none">Drive decision-quality data and learning:</span></strong><span data-contrast="none"> apply quantitative rigor to assay performance and data QC and translate outputs into insights that inform next experiments and, over time, Helicon optimization.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <p><strong>Required qualifications:</strong></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">PhD in Chemical Biology, Biochemistry, Chemistry, Bioengineering, or a related discipline, with 0-2 years’ postdoctoral and/or industry experience.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Strong hands-on experience developing, optimizing, and executing experimental assays (biochemical, biophysical, and/or cell-based), with demonstrated attention to detail and reproducibility.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Quantitative approach to assay quality and performance, including comfort with controls, variability, robustness, and data QC to produce decision-quality readouts.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Demonstrated scripting and tool-building experience (Python or similar) beyond ad hoc “vibe coding,” with examples of using code to automate analyses, streamline workflows, or solve recurring operational problems.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto">Ability to work cross-functionally and communicate clearly with chemistry, biology, and data-focused colleagues.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto">Demonstrated use of AI tools in your current role and responsibilities is required; advanced or innovative use is a plus.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <p><strong><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}">Preferred qualifications:</span></strong></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Experience improving lab throughput through automation or semi-automation, or strong aptitude and interest in learning and applying automation technologies in a screening environment.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Familiarity with high-throughput screening concepts and scaling assay workflows to support large sample numbers.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Working knowledge of peptide chemistry and/or peptide discovery concepts is a plus but not required.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <p><strong><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}">Ways of working that matter here:</span></strong></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="12" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">A builder mindset with strong scientific judgment: you identify bottlenecks, choose the least-resistant path to improvement, and execute with urgency.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="12" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Curiosity for emerging technologies and a practical approach to evaluating what could improve workflow robustness, automation, or assay quality.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="12" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Highly collaborative, low-ego, can-do attitude with consistent follow-through and strong ownership of results.</span><span data-ccp-props="{"134233279":true,"335551550":6,"335551620":6}"> </span></li> </ul> <p><strong>Core Values</strong></p> <p>Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.</p> <ul> <li><strong>Growth-Minded</strong>. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.</li> <li><strong>In(ter)dependent.</strong> We are fiercely <em>independent</em> as a leader in defying the limitations of current therapeutic modalities, and <em>interdependent</em> as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.</li> <li><strong>Patient-focused. </strong>We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.</li> <li><strong>All-In. </strong>We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.</li> </ul> <p><span style="font-weight: 400;">The base salary range for this position is $110,000-125,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive<strong> </strong>benefits designed to support our employees’ overall well-being.</span></p> <p><span style="font-weight: 400;">As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.</span></p> <p><span style="font-weight: 400;"><span style="font-weight: 300;">30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com</span></span></p>