Scientist I – Bioanalytical & Advanced Assay Development

<div class="content-intro"><p data-pasted="true"><strong>About Tonix*</strong></p> <p>Tonix is a fully integrated biotechnology company, publicly traded on NASDAQ (ticker: TNXP), with marketed products and a pipeline of development candidates The Company is focused on commercializing, developing, discovering, and licensing therapeutics to treat and prevent human disease. In August 2025, Tonix received FDA approval for Tonmya™ (cyclobenzaprine HCl sublingual tablets), a first-in-class, once-daily, non-opioid treatment for fibromyalgia. Tonmya is the first new fibromyalgia therapy approved in over 15 years, following successful Phase 3 trials demonstrating significant symptom improvement. Commercial launch is expected in the fourth quarter of 2025. Tonix also markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg, both indicated for the treatment of acute migraine with or without aura in adults.</p> <p>Tonix’s development portfolio includes product candidates in central nervous system (CNS), immunology, immuno-oncology infectious disease and rare disease. The CNS pipeline features both small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions. The immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. The infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, which also serves as a live virus vaccine platform for other infectious diseases. Finally, the rare disease portfolio includes a product in development for Prader-Willi syndrome, which has both orphan drug designation and rare pediatric disease designation grants from the FDA.</p> <p>Tonix owns and operates a state-of-the art infectious disease research facility in Frederick, Md.</p> <p>Please visit www.Tonixpharma.com for specifics on the pipeline.</p> <p>*All of Tonix’s product candidates are investigational new drugs or biologics and have not been approved for any indication.</p></div><p><strong>Position Overview</strong></p> <p>Tonix Pharmaceuticals is advancing a diverse portfolio of therapies, including antivirals, biologics, small molecules, and vaccines in infectious diseases and immunology. We are seeking a Scientist-II to expand our bioanalytical assay development capabilities, supporting programs from discovery through translational and regulatory milestones. This role provides the opportunity to design and validate robust bioanalytical and cell-based assays that directly support Tonix’s therapeutic pipeline, while generating high-quality data that drives preclinical and clinical decision-making</p> <p><strong>Key Responsibilities</strong></p> <p> </p> <p> </p> <p> </p> <p> </p> <ul style="margin-top: 0in; margin-bottom: 0in;" type="disc"> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Bioanalytical Assay Development</span><span style="font-family: Arial; font-size: 11.0pt;"> – Design, develop, optimize, and execute assays supporting potency, neutralization, immunogenicity, biomarker detection, ADME/DMPK, and oncology programs under guidance of senior scientists.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Cell-Based Assay Development</span><span style="font-family: Arial; font-size: 11.0pt;"> – Establish and refine functional 2D and 3D cell-based assays to evaluate biological activity, target engagement, and mechanism of action of therapeutic candidates.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Organoid & iPSC Model Implementation</span><span style="font-family: Arial; font-size: 11.0pt;"> – Culture, maintain, and characterize human organoids and iPSC-derived differentiated cell systems to support disease modeling, efficacy testing, and translational studies. Perform routine passaging, differentiation, quality control, and assay integration.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">3D Culture & Bioprinting Support</span><span style="font-family: Arial; font-size: 11.0pt;"> – Assist in development and optimization of 3D culture systems, bioprinted tissue constructs, and micro physiological models to improve physiological relevance of screening platforms.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Computational & Data Skills for 3D Platforms </span></li> <ul style="margin-top: 0in; margin-bottom: 0in;" type="disc"> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-family: Arial; font-size: 11.0pt;">Utilize image analysis software (e.g., Harmony, ImageJ/Fiji, CellProfiler, or equivalent) for quantitative phenotypic analysis</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-family: Arial; font-size: 11.0pt;">Work with 3D reconstruction tools and segmentation algorithms for organoid/tissue models</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-family: Arial; font-size: 11.0pt;">Manage bioprinting design files (e.g., CAD-based inputs, G-code workflows where applicable)</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-family: Arial; font-size: 11.0pt;">Apply basic scripting (Python/R preferred) for data processing, visualization, and statistical analysis</span></li> </ul> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Biochemical & Biophysical Assays</span><span style="font-family: Arial; font-size: 11.0pt;"> – Execute and optimize ELISA, MSD, enzymatic, binding, and label-free assays (e.g., Octet/BLI, SPR) to characterize potency, kinetics, and molecular interactions.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Experimental Execution & Troubleshooting</span><span style="font-family: Arial; font-size: 11.0pt;"> – Conduct feasibility studies, optimize assay parameters, troubleshoot technical challenges, and ensure reproducibility and robustness of experimental workflows.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 11.0pt;">Data Analysis & Documentation</span><span style="font-family: Arial; font-size: 11.0pt;"> – Analyze experimental data</span><span style="font-family: Arial; font-size: 12.0pt;"> using appropriate statistical tools; maintain accurate laboratory records; prepare summaries, technical reports, and SOP documentation to support development programs.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 12.0pt;">Regulatory & Quality Compliance</span><span style="font-family: Arial; font-size: 12.0pt;"> – Perform work in accordance with company SOPs, quality standards, and applicable regulatory guidelines.</span></li> <li style="margin-top: 0; margin-bottom: 0; vertical-align: middle;"><span style="font-weight: bold; font-family: Arial; font-size: 12.0pt;">Cross-Functional Collaboration</span><span style="font-family: Arial; font-size: 12.0pt;"> – Work closely with biology, pharmacology, DMPK, and translational teams to support candidate progression across Tonix’s therapeutic and vaccine pipeline</span></li> </ul> <p> </p> <p> </p> <p> </p> <p> </p> <p><strong>Necessary Skills and Abilities</strong></p> <ul> <li><strong>Bioanalytical Expertise:</strong> Proven track record developing and validating bioanalytical assays for potency, neutralizing antibodies, immunogenicity, and biomarkers.</li> <li><strong>Assay Development Skills:</strong> Strong background in high-throughput and 384-well cell-based assay design, with applications in drug discovery and translational research</li> <li><strong>Hands-on experience with mammalian cell culture</strong>; 3D culture and/or organoid systems preferred.</li> <li><strong>Technical Skills:</strong> Proficiency in qPCR ELISA, MSD, high-content imaging, and automated assay workflows.</li> <li><strong>Familiarity</strong> with bioprinting systems, CAD design inputs, or digital tissue modeling preferred</li> <li><strong>Software Proficiency</strong> of data analysis tools (GraphPad Prism, Excel, Python, R, or similar)<strong> </strong>and advanced bioanalysis/image analysis tools.</li> <li><strong>Research Record: </strong>Publications and assay development experience that reflect innovation, impact, and strong scientific execution.</li> <li><strong>Critical Thinking & Communication:</strong> Ability to interpret complex datasets and clearly communicate findings to scientific and non-scientific stakeholders.</li> </ul> <p id="isPasted"><strong>Educational and Experience Requirements</strong></p> <ul> <li>PhD in Biochemistry, Molecular Biology, Cell Biology, bioengineering, or related field.</li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="title">Salary Range</div><div class="pay-range"><span>$70,000</span><span class="divider">—</span><span>$120,000 USD</span></div></div></div><div class="content-conclusion"><p><strong>*<span data-teams="true">Please note that Tonix does not offer sponsorship for this role.</span></strong></p> <p><strong>Recruitment & Staffing Agencies</strong></p> <p>Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes.</p> <p><strong>Compensation & Benefits</strong></p> <p>Tonix provides a comprehensive compensation and benefits package which includes:</p> <ul type="disc"> <li>Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short- and Long-Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs</li> <li>Pet Insurance</li> <li>Retirement Savings 401k with company match and annual discretionary stock options</li> <li>Generous Paid Time Off, Sick Time, & Paid Holidays</li> <li>Career Development and Training</li> </ul> <p>Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law.  In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment.  This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training.  Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.</p> <p> </p></div>