Scientist, Computational Chemistry

<meta><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Position Summary:&nbsp;</strong></b><span style="font-size:10pt;white-space:pre-wrap;">We are looking for a highly motivated scientist, ideally with a recent Ph.D. and a few years of </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">postdoctoral or industry experience, to help drive our computational drug discovery and methods development</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">efforts. In this role, you will be responsible for the implementation, rigorous benchmarking, and routine </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">application of state-of-the-art computational chemistry methods. You will work directly with leadership to help </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">expand and maintain a robust computational pipeline that integrates physics-based simulations and semi-empirical </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">quantum mechanics calculations to guide molecular design. Special emphasis will also be placed on coordination </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">and integration with machine learning methods, where the tools are meant to both generate synthetic data for ML </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">models and augment them in parallel. This position will be part of the molecular design team, working closely </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">with informatics, design, molecular data, and machine learning teams, all part of the computational and data </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">sciences (CDS) team at Terray Therapeutics. </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">This is a hands-on role for a scientist who is passionate about applying first-principles thinking to solve challenging </span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">problems in drug discovery, and is eager to work in a collaborative, fast-paced environment.</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">The core responsibilities of this position are:&nbsp;</span></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Implement, Validate &amp; Benchmark</strong></b><span style="font-size:10pt;white-space:pre-wrap;"> a suite of computational chemistry methods, including absolute and relative binding free energy calculations (ABFE/RBFE), enhanced sampling molecular dynamics methods, and semi-empirical quantum mechanical methods (SEQM). The role will involve using open-source code libraries OpenMM, OMSF, RDKit, xTB, and custom in-house code libraries written in Python</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Develop &amp; Maintain Free Energy Calculation Deployment Code and Database</strong></b><span style="font-size:10pt;white-space:pre-wrap;"> with cloud deployment capable of continuous method calibration across multiple projects that can support multiple users. This will involve utilizing best practices in Python-based workflows, knowledge of cloud-based deployment infrastructure (AWS Batch), and robust database strategies</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Project Impact:</strong></b><span style="font-size:10pt;white-space:pre-wrap;"> Apply established methods to active drug discovery projects, analyzing data, interpreting results, and providing actionable insights to guide molecular design and medicinal chemistry efforts</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Stay Current:</strong></b><span style="font-size:10pt;white-space:pre-wrap;"> Continuously survey the scientific literature to identify and champion emerging methods and technologies in computational chemistry and AI-driven drug discovery</span></li></ul><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Experience and Qualifications:&nbsp;</strong></b><span style="font-size:10pt;white-space:pre-wrap;">Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged,&nbsp;recognized,&nbsp;and empowered to be creative.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><i><em style="font-size:10pt;white-space:pre-wrap;">Required Qualifications:</em></i><span style="font-size:10pt;white-space:pre-wrap;">&nbsp;</span></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">BS/MS/Ph.D. in computational chemistry, theoretical chemistry, chemical physics, biophysics, or a related field</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Experience setting up, running, and analyzing molecular dynamics and free energy simulations (e.g., FEP, ABFE, OpenMM) and quantum chemistry methods (xTB)</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Proficiency in Python programming for data analysis, workflow automation, tool development, cloud deployment, and databasing methods</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">A strong understanding of the physical principles underlying molecular interactions, thermodynamics, and kinetics in the context of protein-ligand binding</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Excellent problem-solving skills, the ability to work both independently and as part of a collaborative team, and strong attention to detail in both code syntax and simulation setup details</span></li></ul><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><i><em style="font-size:10pt;white-space:pre-wrap;">Preferred Qualifications:</em></i></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">1-3 years of experience as a computational chemist in the biopharma industry or a relevant post-doc</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Familiarity with cheminformatics toolkits like RDKit, knowledge of containerization technologies (e.g., Docker), experience working in cloud compute environments (AWS Batch, S3)</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Experience with Python for database interaction and management (e.g., using Python libraries like psycopg2, sqlite3, or ORMs like SQLAlchemy to interact with SQL databases)</span></li><li style="font-size:10pt;margin:3px 0px;letter-spacing:0.25px;line-height:1.6;"><span style="font-size:10pt;white-space:pre-wrap;">Familiarity with machine learning for drug discovery methods such as protein co-folding models and potency prediction models (Boltz, OpenFold etc).</span></li></ul><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><br></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:10pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:left;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Compensation Details:</strong></b><span style="font-size:10pt;white-space:pre-wrap;">&nbsp;$140,000 - $216,000&nbsp;(annually) depending on experience; participation in the Company's option plan; 3%&nbsp;retirement safe harbor&nbsp;contribution;&nbsp;fully-paid&nbsp;medical, dental, vision,&nbsp;life,&nbsp;and disability&nbsp;benefits.&nbsp;&nbsp;</span></p> <meta><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><b><strong style="font-size:10pt;white-space:pre-wrap;">Company Overview:</strong></b><span style="font-size:10pt;white-space:pre-wrap;"> Terray Therapeutics is a venture-backed biotechnology company led by pioneers and long-time leaders in artificial intelligence, synthetic chemistry, automation, and nanotechnology.&nbsp;We’re&nbsp;generating chemical data purpose-built to propel drug discovery into the information age — and&nbsp;we’re&nbsp;doing it on a larger scale and faster than has ever before been possible.&nbsp;</span></p><p style="font-family:&quot;Basel Grotesk&quot;,Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;text-align:justify;"><span style="font-size:10pt;white-space:pre-wrap;">Our closed loop system generates precise chemical datasets at unrivaled scale that work seamlessly with AI to systematically map biochemical interactions between small molecules and causes of disease. Iterative cycles of virtual molecular design and experimentation power AI and machine learning models, which in turn guide the next cycle of design. With a chemistry engine that measures billions of interactions daily and becomes increasingly precise with every cycle, we can answer an unprecedented array of questions — deriving insights that enable us to predictably create drugs for patients in need.&nbsp;</span></p>