Research Associate I/II I-O

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. 

SystImmune Inc. is seeking a motivated Research Associate I/II to join the Bioassay team within the Immuno-Oncology department. This role will support the engineering of complex cell lines and the execution of cell-based immunoassays to enable the discovery and development of novel cancer therapeutics. The ideal candidate will be a strong experimentalist with direct experience in genetic modification (such as lentiviral transduction and knock-in/out) and bioassay execution who thrives in a fast-paced, collaborative environment. 

This is a hands-on laboratory role focused on critical materials generation, assay execution, and data analysis. The successful candidate will maintain high-quality experimental standards while developing deep technical expertise in immuno-oncology drug development. 

This role is full-time onsite in Bothell, WA.

Key Responsibilities
 

• Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, and knock-outs 

• Analyze complex datasets, prepare technical reports, and present findings to internal teams. 

• Perform rigorous batch qualification of critical reagents and cell lines to ensure assay consistency. 

• Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines. 

• Conduct functional assays using Incucyte live-cell imaging, flow cytometry, and ELISA-based platforms. 

• Develop, optimize, and validate cell-based and immunoassays to support drug development programs. 

Qualifications 

Research Associate I: 

• BS or MS in Biology, Immunology, Cell Biology, Bioengineering, Biochemistry, or related scientific field 

• Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant) 

• Hands-on experience with mammalian cell culture techniques and aseptic techniques 

• Experience with mammalian cell culture techniques 

• Exposure to genetic modification workflows such as transient transfections or lentiviral transduction 

• Basic familiarity executing immunoassays such as ELISA or flow cytometry 

• Strong organizational skills and attention to detail 

• Ability to work effectively in a team environment 

Research Associate II: 

• BS or MS in a relevant scientific discipline 

• Typically, 2–4 years of relevant industry experience 

• Direct experience engineering cell lines, including executing lentiviral transductions and knock-ins 

• Proven track record executing and troubleshooting cell-based assays and flow cytometry workflows 

• Demonstrated ability to work with moderate independence 

Preferred Qualifications 

• Experience supporting oncology, immuno-oncology, immunology, or biologics drug discovery programs. 

• Experience with single-cell cloning, CRISPR/Cas9 workflows, or stable cell line selection. 

• Proficiency with Incucyte live-cell imaging, multi-color flow cytometry, or MSD multiplex platforms. 

• Exposure to high-throughput research settings or regulated laboratory environments. 

• Strong data analysis software skills (e.g., GraphPad Prism, FlowJo) and scientific communication skills 

Compensation and Benefits: 

The expected base salary range for this position is 60,000 - 80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills. 

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role. 

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE. 

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. 

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.