Research Associate I/II – Clinical Pathology/IHC Biomarker Development

<div><div style="width:6.6493in;"><div style="width:6.6493in;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;">SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.<br>&#160;<br><span style="line-height:normal;">We are seeking a highly organized and detail-oriented <b>Research Associate I/II</b> to support the development, optimization, and validation of immunohistochemistry (IHC) assays. This role will contribute to early-stage biomarker in support of clinical trial programs.</span><br><br><span style="line-height:normal;">The ideal candidate will have <b>2&#8211;3 years of hands-on industry experience</b> in histology, IHC, or a regulated laboratory environment (e.g., CLIA/CAP, GLP). This is a <b>bench-focused position</b> requiring close collaboration with scientists, pathologists, and cross-functional project teams.</span></span></span><br><br><br><span style="font-size:16px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Key Responsibilities</b></span></span></span><br><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Histology</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Perform tissue sectioning of FFPE blocks.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Route and support H&amp;E staining workflows.</span></span></span></li></ul><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>IHC Assay Execution</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Perform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica).</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Assist in generating feasibility, optimization, and analytical validation data for emerging CDx assays.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Experience with <b>Akoya PhenoImager</b> HT platforms is preferred.</span></span></span></li></ul><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Sample &amp; Workflow Support</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Manage tissue samples and associated documentation.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Maintain sample integrity, traceability, and documentation in compliance with quality system requirements.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Support tissue handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments.</span></span></span></li></ul><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Data Collection &amp; Documentation</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Accurately record experimental data in ELN and/or LIMS systems.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Capture high-quality slide images and perform basic image analysis.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Assist with slide scoring preparation and data summaries.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Summarize experimental findings for internal meetings and assay development reviews.</span></span></span></li></ul><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Instrument &amp; Laboratory Maintenance</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Operate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Monitor and manage inventory of reagents, antibodies, controls, and consumables.</span></span></span></li></ul><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Cross-functional Support</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Collaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Support preparation of study materials, controlled documents, and protocol execution for validation studies.</span></span></span></li></ul><div style="margin-bottom:11px;"><br><span style="font-size:16px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Qualifications</b></span></span></span><br><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Required</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">BS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>1&#8211;3 years of hands-on experience</b> in histology and/or IHC assay execution within a research or regulated diagnostic laboratory.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Experience handling FFPE tissues and operating automated IHC staining platforms.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Strong attention to detail with excellent documentation and record-keeping practices.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Ability to follow SOPs and work effectively in CLIA-, GxP-, or ISO-regulated environments.</span></span></span></li></ul><br><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;"><b>Preferred</b></span></span></span><ul style="margin-bottom:11px;"><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Experience supporting IHC assay optimization and/or analytical validation studies.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Exposure to <b>Akoya platforms</b> and <b>multiplex immunofluorescence</b> projects.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Experience with digital pathology, slide scanning, or image analysis tools.</span></span></span></li><li style="margin-bottom:11px;"><span style="font-size:14px;"><span style="font-family:Arial, Helvetica, sans-serif;"><span style="line-height:normal;">Knowledge of antibody characterization and tissue-based biomarker assay development.</span></span></span></li></ul>