Description

Actinium is seeking an individual to lead the next wave of breakthroughs in targeted radiotherapies as our Senior/Principal Scientist, Radiochemistry. In this high-impact role, you will serve as the scientific leader for all radiochemistry efforts across our Oncology pipeline, shaping novel targeted radiotherapies from concept through IND-enabling studies. You will join a fast-paced, science-driven biotech developing first-in-class targeted radiotherapies with the potential to transform outcomes across solid tumors. The ideal candidate is an expert in radiochemistry, radiometal chelation, and radioconjugate design, with deep experience spanning both therapeutic and imaging radionuclides (e.g., Ac-225, Lu-177, Zr-89, In-111, Cu-64, Ga-68). A strong track record in PET/SPECT imaging agent development, chelator optimization, and structure-function evaluation is highly desirable. This is a unique opportunity to drive innovation across isotope selection, chelator architecture, conjugation chemistry, dosimetry-enabling imaging, and translational development for targeted radiotherapies in a rapidly expanding organization.

Requirements

Ph.D. in Radiochemistry, Organic Chemistry, Radiopharmaceutical Sciences, Nuclear Pharmacy, or related field. 8-10+ years of industry/academic experience developing targeted radiotherapies and/or radiopharmaceutical imaging agents (PET/SPECT), from discovery through IND filings. Extensive hands-on expertise with radiometal chelation, bifunctional chelator design (e.g., DOTA and emerging ligand systems), and bioconjugation chemistry. Demonstrated experience with therapeutic isotopes (Ac-225, Lu-177) and imaging isotopes (Zr-89, Cu-64, In-111, Ga-68) including radiolabeling, purification, stability studies, and in vivo translation. Strong track record in developing PET/SPECT imaging agents, imaging-guided dosimetry, and translational radionuclide imaging. Expertise with analytical and radiochemical instrumentation (size-exclusion HPLC, radio-HPLC, radio-TLC, gamma spectrometry, LC-MS a plus). Proven ability to lead programs through preclinical development into regulatory submission, with authorship of publications, patents, or regulatory documents. Strong critical thinking, creativity, and scientific curiosity, with an entrepreneurial mindset and ability to thrive in a fast-growing biotech environment. Exceptional written and oral communication skills, with the ability to influence across functions and present to technical and non-technical audiences.

Principal Scientist Radiochemistry

Description

Requirements

Actinium Pharmaceuticals