Principal Scientist In Vivo Immunology

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
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Our approach to R&D

Job Purpose: 

The Principal Scientist in the in vivo immunology team will serve as the preclinical in vivo study lead and will represent the project team in spearheading GSK’s innovation of novel viral vaccines and platform programs. You will have the opportunity to lead the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team. You will design and write in vivo study protocols, coordinate and initiate preclinical studies, conduct and analyze experimental results pertaining to the understanding of the immune responses from novel vaccine candidates, formulations, and platforms.

Key responsibilities:

This role will provide you with the opportunity to lead key activities and to progress your career based on performance. The responsibilities include the following:

• Design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs. May serve as the preclinical in vivo lead.

• Implement and ensure adherence to GSK and regulatory requirements for compliance with Institutional Animal Care and Use Committee (IACUC) guidelines through writing and reviewing in vivo study protocols and participating in the independent scientific review committee.

• Conduct dosing, In Vivo Imaging System (IVIS) imaging, necropsy, and tissue harvest from animal studies and supervise technicians conducting these activities

• Perform experiments characterizing cell-mediated immune response for preclinical immunogenicity or challenge studies using flow cytometry, Enzyme‑Linked ImmunoSpot (ELISPOT), Luminex or Meso Scale Discovery (MSD) assays and others.

• As a preclinical in vivo study lead, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.

• Prepare and document study protocols and final reports for projects as an author.

• Contribute to patent filing, Investigational New Drug (IND) submissions, and scientific publications.

• Present study plans and results at project meetings.

• Develop new experimental techniques based on project needs.

• Mentor and train junior scientists.

Basic qualifications

• Doctor of Philosophy (Ph.D.) or Master of Science (M.S.) degree in immunology or a related field.

• 4+ years of working experience post Ph. D or 6+ years of working experience post M.S in immunology or in these related field.

• Experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.

• Experience in small rodent handling and drug administration, in-study blood sampling, necropsy, tissue harvest, and processing.

• Experience in designing, executing, and analyzing immune response readouts using conventional or spectral flow cytometry.

Preferred qualifications

• Matrix management experience. A collaborative team player with strong interpersonal skills to work with diverse groups within the organization.

• Detail-oriented with the agility to balance multiple projects.

• Extremely organized with experience in documentation of study protocols and reports.

• Experience with immune-response related readout methods such as ELISPOT, Luminex, and qPCR methodologies.

• Experience preparing and delivering written and verbal communications in a professional setting.

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• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $115,500 to $192,500. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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