Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)
Novartis
This listing was originally posted on Novartis's careers page. Formulate is an equal opportunity job aggregator and is not involved in the hiring process. Where salary information is estimated, it is derived from BLS industry benchmarks and may differ from actual compensation.
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Job Description
Key Responsibilities:
Develop, validate, and implement immunoassay- and LC-MS–based methods to quantify exploratory soluble biomarkers for clinical programs across the Novartis portfolio, with a primary focus on neuromuscular and muscle disease programs.
Apply hands-on assay development expertise to build robust, fit-for-purpose biomarker methods that support clinical decision-making and advance translational science objectives.
Serve as the scientific and technical lead for exploratory soluble biomarker assays, including assay strategy, data quality, interpretation, documentation, and alignment to context of use and clinical study endpoints.
Translate disease biology and program needs into clear biomarker assay plans in partnership with project teams, Translational Medicine, Clinical, Data Science, and external collaborators.
Evaluate and implement innovative assay technologies and workflows to improve assay sensitivity, specificity, reproducibility, throughput, and biological relevance for neuromuscular indications.
Analyze, interpret, and communicate biomarker and assay data to key stakeholders, project teams, and cross-functional stakeholders to support timely, evidence-based decisions.
Partner with internal line functions and external vendors to deliver high-quality fit-for-purpose biomarker assays, and sample analysis activities within agreed timelines.
Maintain high standards for scientific rigor, documentation, data integrity, compliance, safety, and technical excellence in accordance with applicable Novartis policies and procedures.
Essential Requirements:
PhD with 2+ years of experience in drug discovery, translational research, or related field; or Master’s degree with 10+ years of experience in the pharmaceutical/ biotech industry.
Strong hands-on experience developing, optimizing, validating, and troubleshooting immunoassays (ELISA, MSD, Luminex, Simoa) and LC-MS methods of varying complexity for soluble biomarkers.
Experience with tissue biopsies, particularly muscle tissue, and associated assays or workflows such as IHC/IF, tissue collection, processing, and sample handling best practices.
Solid experience supporting neuromuscular, muscle, or related disease biology programs, with the ability to connect assay strategy with the biomarker plan.
Demonstrated ability to design rigorous experiments, solve complex technical problems, assess assay performance, and communicate conclusions clearly to scientific and non-scientific stakeholders.
Experience working in cross-functional project teams and managing internal or external assay development activities, timelines, deliverables, and scientific documentation.
Excellent oral and written communication skills, including the ability to present scientific strategy, data, risks, and recommendations clearly.
Commitment to working collaboratively in an inclusive environment and role-modeling Novartis values and behaviors.
Desirable Requirements:
Experience with genomic, transcriptomic, proteomic, or other multi-omics approaches, including RNA-seq or related platforms.
Strong understanding of circulating muscle proteins, including structural and functional biomarkers relevant to muscle disease biology.
The salary for this position is expected to range between: $108,500 and $201,500 per year.
The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
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EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Salary Range
$108,500.00 - $201,500.00
Skills Desired
Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Curious Mindset, Data Analysis, Detail-Oriented, Drug Development, Ethics, Gene Therapy, Immunology, Inventory Management, Machine Learning (ML), Medical Research, Molecular Biology, Python (Programming Language), ScienceExplore related positions you might be interested in
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