Principal Scientist, Discovery Chemistry

SanegeneBio is a clinical-stage biotechnology company developing innovative genetic medicines based on RNAi (RNA interference) technology. Powered by the proprietary LEAD™ (Ligand and Enhancer Assisted Delivery) RNAi delivery and chemistry platform, SanegeneBio has a growing pipeline across several therapeutic areas including cardiometabolic and complement-mediated diseases. SanegeneBio has R&D operations in Boston, Suzhou and Shanghai. This role focuses on the design and synthesis of siRNA conjugates to advance novel RNAi delivery technologies. This individual plays a critical role in developing delivery strategies and driving project development, with particular emphasis on the ligand identification/optimization, conjugates design/synthesis, and SAR (Structure-Activity Relationships) design/analysis. Key Responsibilities include designing, executing, and optimizing siRNA conjugations with targeting ligands, analyzing SAR data, optimizing targeting ligands, maintaining productivity to deliver siRNA in alignment with project goals, contributing to platform innovations, and mentoring junior chemists.