Associate Medical Director, Neurology Clinical Development

Position Purpose:

The Medical Director Neurology Clinical Development will play a key role in the planning, execution, and interpretation of clinical studies focused on transformative therapies for life-threatening neurological diseases. This individual will contribute medical and scientific expertise to advance programs from early development through late-stage studies and regulatory submission.

The Medical Director will support cross-functional teams, interface with external partners and investigators, and help ensure the highest standards of scientific and clinical rigor are maintained across all programs. This role will report to the Senior Medical Director in Neurology Clinical Development.

Key Responsibilities:

Clinical Development & Execution

• Support the design, implementation, and oversight of clinical trials in neurology, including protocol development, study conduct, and data analysis
• Contribute to the medical and scientific content of key clinical documents (e.g. protocols, investigator brochures, clinical study reports, and regulatory submissions)
• Participate in clinical data review, interpretation, and presentation to support timely and informed decision-making
• Collaborate with safety/pharmacovigilance on safety review and signal evaluation
• Provide medical monitoring and clinical oversight for ongoing studies under the supervision of the Medical Director or Senior Medical Director
• Maintain effective collaboration with CROs, investigators, and academic partners to ensure study quality and adherence to timelines
• Ensure compliance with GCP, ICH, and all applicable regulatory and ethical guidelines

 

Scientific & Strategic Contribution

• Support the development of clinical development strategies and study designs in alignment with program objectives and scientific rationale
• Contribute to the development, execution, and continuous refinement of global Clinical Development Plans (CDPs)
• Integrate emerging data, literature, and competitive intelligence to inform ongoing program decisions and ensure scientific relevance and rigor
• Collaborate closely with cross-functional partners including regulatory, clinical development operations, and biostatistics to ensure consistency and accuracy in study execution
• Participate in internal discussions and presentations to communicate key scientific insights, data interpretations, and development updates
• Contribute to the preparation and review of strategic and regulatory documents, including target product profiles, clinical sections of IND/CTA submissions, and briefing packages

External Engagement & Communication

• Engage and collaborate with key opinion leaders (KOLs) and academic investigators to inform study designs and strengthen the scientific foundation of development programs
• Represent the clinical development organization at scientific and medical meetings, advisory boards, and key investigator interactions
• Contribute to the authorship of abstracts, manuscripts, and scientific presentations that communicate program progress and data to the broader scientific and clinical community

Leadership & Collaboration

• Provide clinical and scientific leadership with cross-functional clinical teams, fostering an environment of accountability, curiosity, and collaborative problem solving
• Partner effectively with internal stakeholders across clinical development operations, biostatistics, regulatory, and commercial to ensure scientific and operational excellence in study execution
• Serve as a clinical development point of contact in collaborations and partnerships, helping to maintain strong relationships built on scientific integrity, transparency, and shared objectives

Required Skills & Experience:

• MD, MD/PhD candidates with relevant clinical development experience in neurology, rare/orphan, or genetic diseases
• Board certified or eligible in neurology, pediatrics, or a relevant specialty (for MDs)
• Minimum 5 years’ experience contributing to the design, conduct, or medical oversight of clinical trials including industry experience required
• Familiarity with FDA/EMA regulations and ICH/GCP guidelines
• Strong scientific, analytical, and organizational skills
• Demonstrated ability to interpret complex clinical and scientific data
• Excellent communication and presentation skills, with the ability to collaborate effectively across multidisciplinary teams
• High personal integrity, scientific rigor, and strong commitment to advancing therapies for patients with serious neurological diseases

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position, currently based in Bedford and will later be based in Waltham.

Travel:

This position will require approximately 20% travel (domestic and international).

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $269,000 - $331,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location.  In addition to base salary, Stoke offers an annual bonus and   equity participation.

Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).