Manager or Sr. Manager, Clinical Supply Chain

<p><strong>Location:  </strong><span data-teams="true">This position may be performed remotely, but requires the flexibility and willingness to travel as needed.</span></p> <p><strong>The Opportunity</strong></p> <p data-start="112" data-end="562">We’re looking for a knowledgeable and detail-oriented Manager or Senior Manager of Clinical Supply Chain to ensure our clinical trials are always ready to run - without delay, disruption, or waste.  You'll be responsible for the end-to-end planning, execution, and oversight of clinical supply activities for assigned clinical programs and studies. You'll manage across the full study lifecycle, from protocol development and study startup through closeout, ensuring uninterrupted supply, regulatory compliance, and operational excellence.</p> <p>This role calls for an experienced clinical supply pro who can manage complexity, proactively identify and mitigate risk, and partner across teams to support Praxis’s clinical development objectives. </p> <p><strong>Primary Responsibilities</strong></p> <ul> <li>Supply strategy development for assigned clinical programs or studies, including forecasting and demand planning as well as packaging, labeling, and distribution oversight</li> <li>Depot and site supply management</li> <li>Returns, reconciliation, and destruction</li> <li>Develop and maintain integrated supply plans aligned with protocol requirements and study timelines.</li> <li>Support study startup activities, including IRT design input, pharmacy manual development, and vendor onboarding.</li> <li>Monitor supply performance throughout study execution and proactively resolve issues related to supply shortages, excursions, and distribution challenges.</li> <li>Manage relationships with clinical supply vendors (e.g., depots, packaging/labeling vendors, couriers, IRT providers).</li> <li>Lead vendor forecasting discussions, review performance metrics, and manage issue resolution.</li> <li>Author, review, and approve clinical supply-related documents, including pharmacy manuals, supply plans, shipping documentation, vendor specifications and work orders</li> <li>Ensure all activities are conducted in compliance with GxP requirements, internal SOPs, and applicable regulations.</li> <li>Support inspection readiness activities and participate in audits and inspections as needed.</li> <li>Identify clinical supply risks and implement mitigation strategies to protect study timelines and patient safety.</li> <li>Support quality events, deviations, CAPAs, and change management activities.</li> </ul> <p><strong>Qualifications and Key Success Factors</strong></p> <ul> <li>Bachelor’s degree in a scientific, clinical, or supply chain–related discipline (or equivalent experience) with a minimum of 5 to 8 years of experience in Clinical Supply management in a pharmaceutical or biotechnology environment – small or mid-sized biotech environment preferred.</li> <li>Experience supporting <strong>Phase 2</strong> and/or <strong>Phase 3</strong> clinical trials strongly preferred.</li> <li>Preferred hands-on experience with DTP/DFP models, IRT systems, and global clinical supply distribution</li> <li>Demonstrated experience managing end-to-end clinical supply activities for clinical trials.</li> <li>Proven ability to independently manage multiple studies simultaneously.</li> <li>Strong working knowledge of GxP requirements and clinical trial operations.</li> <li>Preferred experience supporting audits and regulatory inspections.</li> <li>Strong organizational and project management skills</li> <li>Proactive problem-solving and risk-based decision-making</li> <li>Ability to operate independently with minimal supervision</li> <li>Effective cross-functional communication and stakeholder management</li> <li>Comfort operating in a fast-paced, evolving environment</li> <li>The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.</li> </ul> <p><strong>Compensation & Benefits</strong></p> <p><span data-teams="true">At Praxis, we believe that taking care of our people (and <em>their</em> people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! </span></p> <p>To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.</p><div class="content-pay-transparency"><div class="pay-input"><div class="title">Annualized Base Salary</div><div class="pay-range"><span>$115,000</span><span class="divider">—</span><span>$155,000 USD</span></div></div></div><div class="content-conclusion"><p><strong>Company Overview</strong> </p> <p>Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of <strong>Trust</strong>, <strong>Ownership</strong>, <strong>Curiosity</strong> and <strong>Results</strong> are foundational to every aspect of our business and are exemplified by each and every one of our team members.<br><br><strong>Diversity, Equity & Inclusion</strong><br>Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE<sup>®</sup> to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.<br><br><strong>Attention: Job Scam Alert</strong><br>Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to <a href="mailto:careers@praxismedicines.com">careers@praxismedicines.com</a>.<br><br><strong>Praxis does not accept unsolicited submissions from recruitment agencies for open positions. </strong>We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.</p></div>