This role requires variant interpretation experience in a clinical or equivalent setting

About the Opportunity:

Full-time, US-based remote opportunity

At Genomenon, we are at the forefront of genomics research and innovation, with a mission to accelerate genetic discoveries and improve patient care.

We are seeking a Manager, Product Quality (Variant Interpretation) to lead the scientific rigor, consistency, and scalability of our variant interpretation efforts. This is a high-impact leadership role responsible for ensuring the accuracy and defensibility of data that powers our products, supports clinical decision-making, and informs pharmaceutical research.

As our curation volume, product complexity, and client engagements continue to grow, this role will serve as the scientific authority for complex variant interpretation while building and leading a high-performing QA function. You will shape how interpretation is done at scale—driving standards, improving systems, and mentoring a team of scientists.

If you are passionate about genomics, thrive in complex scientific problem-solving, and want to influence both product and patient impact, this is an opportunity to lead from the front.

Position Responsibilities:

Variant Interpretation & Scientific Leadership

• Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence
• Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications
• Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability
• Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
• Support high-impact client deliverables, including clinical and pharmaceutical use cases
• Germline experience preferred

Quality Assurance & Standards Ownership

• Own QA/QC standards across all variant interpretation workflows
• Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
• Oversee external data quality, including ClinVar submissions and discrepancy resolution

Team Leadership & Development

• Manage, mentor, and develop a team of QA scientists and curators
• Provide coaching on interpretation, evidence evaluation, and best practices
• Set clear performance expectations and maintain accountability for quality standards

Process Improvement & Scalability

• Design, implement, and continuously improve SOPs, QA processes, and workflows
• Identify systemic quality issues and lead solutions that scale across teams and projects
• Balance standardization with flexibility to meet diverse client and product needs

Cross-Functional Collaboration

• Partner with product, engineering, and leadership to improve tools, workflows, and data quality
• Contribute to broader data and product strategy through scientific expertise 

About You:

You are a highly experienced variant interpretation expert who combines scientific depth with leadership capability. You’re comfortable making high-stakes decisions in ambiguous situations, and you take ownership of quality, not just your work, but the work of the team.

You bring a strong QA mindset, a bias toward evidence-based decision-making, and a drive to improve systems.

Required Skills & Experience

• 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting
• Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
• Deep expertise applying ACMG/AMP guidelines in complex scenarios
• Strong experience evaluating clinical and functional evidence from scientific literature
• Proficiency in HGVS nomenclature, including normalization and variant disambiguation
• Demonstrated ability to make independent, high-confidence scientific decisions

Preferred / Nice to Have

• Experience with ClinVar submissions and resolving interpretation discrepancies
• Prior people management or strong leadership experience
• Experience developing SOPs
• Exposure to a broad range of disease areas or gene classes

What You’ll Bring

• Strong scientific judgment, especially in ambiguous or conflicting evidence scenarios
• A rigorous QA mindset with exceptional attention to detail
• Ability to mentor and elevate others
• Process-oriented thinking with a focus on scalability
• Clear, structured communication of complex scientific concepts
• Ownership mentality for quality, team performance, and outcomes

Why Join Genomenon

Own Scientific Quality at Scale
Shape how variant interpretation is performed across products, clients, and public data resources.

Lead and Build
Develop a high-performing team and establish systems that scale with the organization.

Make a Real Impact
Your work directly supports clinical decisions, patient outcomes, and pharmaceutical research.

Tackle Meaningful Complexity
Work on challenging, high-impact problems at the intersection of genomics, data, and real-world application.

Interview Process

• Initial Video Screen
• Technical Video Screen
• Take Home exercise
• Team Panels (2)
• TopGrading Interview