Manager, Antibody Characterization

<p>Twist Bioscience is seeking a highly motivated and enthusiastic Manager, Antibody Characterization to join our dynamic Operations Team. This is an exciting opportunity to lead a critical function within a fast-paced, high-growth synthetic biology environment. The ideal candidate will thrive on the challenge of building new product lines while enforcing the rigor and accountability essential for delivering world-class, high-quality products to both internal and external customers.</p> <p><strong>Onsite - 5 Days per week - Wilsonville, Oregon.</strong></p> <p><strong>What You’ll Be Doing: </strong></p> <ul> <li>Manage, train, and mentor production team members, fostering a collaborative and high-performing laboratory environment.</li> <li>Overseeing, running, and troubleshooting antibody characterization experiments using advanced analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning.</li> <li>Act as the primary point of contact for shift Manufacturing Associates and Specialists, ensuring the team adheres to the plan of record.</li> <li>Provide guidance, oversee priority decisions, and lead troubleshooting efforts for production issues as they arise.</li> </ul> <ul> <li>Establish and track Key Performance Indicators (KPIs) to drive production efficiency and meet department goals.</li> <li>Model capacity and recommend high-throughput workflow options and staffing plans based on demand forecasts.</li> <li>Drive operational excellence by identifying and implementing Continuous Process Improvement (CPI) initiatives to increase capacity, reduce Turnaround Time (TAT), and lower Cost of Goods Sold (COGS).</li> <li>Lead complex technical investigations and risk assessments related to processes, including resolving customer incidents.</li> </ul> <ul> <li>Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations.</li> <li>Develop and revise Standard Operating Procedures (SOPs), work instructions, and training documents for the characterization of proteins/antibodies.</li> <li>Ensure the team operates in compliance with necessary quality standards.</li> </ul> <ul> <li>Collaborate with internal and external customers on protein production projects</li> <li>Work closely with the Director and support functions to evaluate opportunities for product line improvements, contributing to Twist's strategic vision.</li> <li>Lead cross-functional projects, including running recurring status meetings and managing assignments across teams in the US, Europe, and Asia.</li> </ul> <h3><strong>What You'll Bring to the Team</strong></h3> <ul> <li>B.S. or M.S. degree in Biology, Biochemistry, Immunology, Process Engineering, or a related field.</li> <li>5+ years of experience in the biotech/pharmaceutical industry, preferably involving the characterization of diagnostic and/or therapeutic antibodies.</li> <li>Strong understanding of antibody discovery, preferably focusing on assay development and protein characterization</li> <li>Previous experience with BLI, SPR, and ELISA strongly preferred.</li> <li>A proven track record of successfully developing and manufacturing protein-based commercial products.</li> <li>Demonstrated scientific leadership, mentoring, and organizational skills in managing direct reports and overseeing external collaborations (e.g., CROs).</li> <li>Deep expertise in basic synthetic/molecular biology skills, including Mammalian Cell Culturing, Transfection, Buffer Exchange, and molecular biology workflows.</li> <li>Excellent project management skills: proficient with timeline development, project tracking, and the ability to efficiently manage and prioritize multiple projects.</li> <li>Exceptional attention to detail, organizational, and record-keeping skills.</li> <li>Familiarity with PLM, ERP, and MES management systems is a plus.</li> </ul> <p><span style="color: #ffffff;">#LI-LK1</span> </p>