LC-MS Chemist - Metabolism

Labcorp is seeking an LC-MS Chemist – Metabolism to join our team in Madison, WI.

Work Schedule:  Monday - Friday 8:00 am - 5:00 pm

Job Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
• Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
• Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
• Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
• Collaborate effectively with colleagues across the Bioanalytical site and support cross-functional communications with external clients.
• Train and mentor less experienced laboratory staff.
• Contribute to process improvement initiatives and participate in department-wide quality initiatives.
• Maintain a clean, safe, and organized laboratory environment.

Minimum Qualifications:

• Bachelor's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 2 or more years hands-on experience with LC-MS/MS bioanalysis, including MRM-based quantitation and method execution.
• 2 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK-MDR1), and PK sample processing (plasma, tissue lysates).
• 2 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

Preferred Qualifications:

• 1 or more years of exposure to CYP inhibition or Time-Dependent Inhibition (TDI) assays and drug-drug interaction (DDI) studies.
• 1 or more years of experience assisting in the development or optimization of new bioanalytical methods.
• Master's degree or other post graduate studies in a relevant life sciences discipline.

Additional Job Standards:

• Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
• Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
• Strong attention to detail with demonstrated ability to generate reproducible, high-quality bioanalytical data.
• Familiarity with Orbitrap platforms or other high-resolution mass spectrometry systems.
• Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
• Experience working in a GLP/GCP-regulated environment (CRO or pharmaceutical/biotech industry).
• Excellent written and verbal communication skills.
• Proven ability to prioritize workloads and manage time effectively in a fast-paced laboratory environment.

Labcorp is a leading global life sciences company delivering answers for crucial health questions. Through unparalleled diagnostics and drug development capabilities, we empower patients and accelerate innovations for medical, biotech, and pharmaceutical companies. Labcorp Drug Development has contributed to one-third of all prescription medicines on the market today.

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan. For more detailed information, please click here. 

Labcorp is proud to be an Equal Opportunity Employer:

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law. 

We encourage all to apply

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