Executive Director / Senior Director, Project Management Lead

Position Overview 

The Executive Director / Senior Director, Project Management Lead is responsible for leading and developing Immunome’s Project Management function and ensuring consistent, high-quality project management support across Research and Development programs and functional teams. This role focuses on strengthening alignment, transparency, and execution discipline across cross-functional and program teams, while establishing scalable project management standards, governance practices, and enterprise tools.  

The Executive Director / Senior Director will oversee the project management team, ensure consistent application of planning and reporting frameworks, and partner closely with functional and program leadership to drive operational cohesion across the organization. This role will also lead Immunome’s Smartsheet platform strategy to ensure standardized communication, reporting, and project visibility across programs and functions.  

This role is ideal for a seasoned project management leader who excels at building high-performing teams, driving consistency across diverse functions, and leveraging enterprise tools to enhance transparency and execution discipline. The Executive Director / Senior Director, Project Management Lead will be instrumental in ensuring Immunome’s programs and functional initiatives are supported by standardized, scalable, and aligned project management practices.  

This position reports to the Senior Vice President of Project and Program Management and plays a key role in reinforcing organizational alignment and execution excellence.  

Responsibilities 

Project Management Team Leadership  

• Lead, mentor, and develop the Project Management team, including hiring, onboarding, coaching, and performance management.  

• Establish clear role definitions, expectations, and accountability standards for project managers embedded within program and functional teams.  

• Ensure consistent training and capability development across the PM team.  

• Assess PM capacity and align resources with evolving program and functional priorities.  

• Foster a culture of rigor, transparency, and continuous improvement within the PM function.  

 

Cross-Functional & Program Team Alignment  

• Partner with leaders across Research, Clinical Development, CMC, Regulatory Affairs, Commercial, Finance, and other operational groups to ensure consistent planning, milestone definition, risk tracking, and reporting practices.  

• Drive alignment between program teams and functional teams to ensure shared visibility into timelines, dependencies, decision points, and resource needs.  

• Standardize integrated planning processes to reduce variability in execution across programs.  

• Ensure transparent identification and management of cross-functional risks and interdependencies.  

• Facilitate structured governance interactions and clear escalation pathways across teams.  

• Smartsheet Platform Leadership & Execution Transparency  

• Lead the strategy, governance, and optimization of Immunome’s Smartsheet platform to support project and program management needs.  

• Establish standardized templates, dashboards, and reporting frameworks to ensure consistent communication across program and functional teams.  

• Drive adoption and disciplined use of Smartsheet as the primary platform for integrated planning, milestone tracking, and status reporting.  

• Ensure data integrity, reporting consistency, and alignment of dashboards with executive governance needs.  

• Partner with functional and program leaders to continuously refine platform utilization to enhance visibility and decision-making.  

• Provide oversight for platform enhancements, integrations, and user enablement to support organizational growth.  

 

Standardization, Governance & PMO Support  

• Lead development and refinement of project management standards, templates, and governance practices.  

• Ensure consistent integrated development plans, status reports, and performance metrics across all supported programs.  

• Partner with PMO leadership to strengthen executive-level reporting and portfolio transparency.  

• Monitor execution trends and identify opportunities to improve alignment, communication, and operational effectiveness.  

 

Program & Functional Initiative Support  

• Provide direct project management leadership for high-priority or complex initiatives as needed.  

• Support cross-functional operational initiatives beyond core development programs (e.g., platform teams, alliance support, strategic initiatives, or organizational projects).  

• Expand PM support into additional functional areas as organizational complexity increases.  

• Ensure new programs and functions are integrated into standardized PM frameworks and tools.  

 

Qualifications 

• Advanced degree (PhD, MD, PharmD, MBA, MS) in Life Sciences, Drug Development, Business Administration, or related field preferred.  

• A minimum of 8-10+ years of experience in biotechnology or pharmaceutical development, including significant cross-functional project management experience.  

• A minimum of 3-5+ years of project management team management experience.  

• Demonstrated experience managing and developing project management professionals.  

• Strong understanding of drug discovery and development processes.  

• Experience implementing standardized project management governance frameworks and enterprise tools.  

• Proven ability to drive alignment across matrixed program and functional teams.  

• Experience leading enterprise-level Smartsheet or comparable project portfolio management platforms strongly preferred.  

• Excellent leadership, communication, and stakeholder engagement skills.  

 

Knowledge and Skills 

• Deep expertise in cross-functional project management within biotechnology or pharmaceutical development.  

• Strong capability in integrated planning, resource alignment, and risk management.  

• Experience building scalable PMO structures and alignment frameworks.  

• Advanced proficiency in Smartsheet, including dashboard development, reporting frameworks, and governance structures.  
• High proficiency in Microsoft Office Suite (Word, Excel, PowerPoint).