Engineer II - Frontline Engineering (Downstream Operations)

Engineer ll – Frontline Engineering

Location: Vacaville, California

Play a critical role at the heart of biopharmaceutical manufacturing, directly supporting life‑saving drug production. As a Frontline Engineer, you will act as a system and equipment subject matter expert, solving complex technical challenges, driving continuous improvement, and ensuring manufacturing readiness in a GMP-regulated environment.

What you will get:

The full-time base annual salary for this position is expected to range between $95,000-$153,000. In addition, below you will find a comprehensive summary of the benefits package we offer:

• Performance-related bonus

• Medical, dental and vision insurance

• 401(k) matching plan

• Life insurance, as well as short-term and long-term disability insurance

• Employee assistance programs

• Paid Time Off

Compensation for this role will be determined by the candidate’s qualifications, skills, experience, and relevant knowledge.

What you will do:

• Directly support 24/7 manufacturing operations as a system and equipment SME, ensuring systems are fit for purpose and ready for use.

• Investigate and assess complex unplanned events, applying structured problem solving and root cause analysis to deliver sustainable solutions.

• Lead and manage small to medium-sized improvement projects, driving operational excellence and reliability.

• Partner cross‑functionally with Manufacturing, Quality Assurance, Engineering, Maintenance, MSAT, Automation, and EHS to deliver on production schedules.

• Provide SME support for startup, commissioning, and qualification of new equipment and systems, including on‑call support as required.

• Analyze equipment and process data to identify trends, recommend improvements, and lead implementation activities.

• Support CAPEX projects and New Product Transfers, contributing technical expertise from conceptual design through qualification.

What we are looking for:

• Bachelor’s degree (or equivalent practical experience) in Engineering, Biotech, Operations, or a related field.

• Strong experience supporting pharmaceutical or biotech manufacturing equipment and systems in a GMP-regulated environment.

• Hands-on experience in downstream biopharmaceutical manufacturing operations within a commercial GMP facility, supporting equipment and processes such as chromatography, viral filtration, ultrafiltration/diafiltration, or bulk drug substance operations.

• Demonstrated project leadership skills with experience delivering improvements and system changes.

• Excellent communication and collaboration skills, with the ability to influence cross‑functional stakeholders.

• Proficiency with tools such as SAP, MS Office, P&IDs, and data visualization tools preferred.

About Lonza

At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone’s ideas, big or small, have the potential to improve millions of lives, and that’s the kind of work we want you to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law.

If you’re ready to help turn our customers’ breakthrough ideas into viable therapies, we look forward to welcoming you on board.

Ready to shape the future of life sciences? Apply now.