Description

<div class="content-intro">Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.</div>Position Overview Immunome is hiring a Director, IT Planning and Program Management to help build and lead our internal IT Project Management Office (IT PMO) from the ground up. This role will establish portfolio governance and decision-making practices, standardize project delivery, and improve transparency and predictability across IT and technology-enabled initiatives. The Director will partner closely with IT and business leaders across Research, Tech Ops, Development, Commercial, and G&amp;A functions to drive predictable delivery of infrastructure and enterprise system implementations that enable scale, portfolio advancement, and commercial readiness in a regulated life sciences environment.&nbsp; Responsibilities Establish and Lead the IT PMO Operating Model <ul> <li>Build Immunome’s enterprise IT PMO from the ground up, including the operating rhythm, standards, templates, and portfolio performance metrics.</li> <li>Define how projects are governed and delivered (IT-led, business-led, and vendor-led) and set clear roles and expectations for project managers and functional project leads.</li> <li>Own IT portfolio financial management (business cases, forecasting, vendor spend tracking, planning and budgeting, and reporting of spend vs actuals) in partnership with IT leadership and Finance.</li> <li>Provide leadership and oversight of the IT PMO team, including internal project managers and external contractors/consulting partners, scaling the team structure, capabilities, and capacity in alignment with company growth and portfolio demand.</li> </ul> Portfolio Intake, Prioritization, and Capacity-Based Planning <ul> <li>Implement end-to-end demand intake and portfolio planning, including intake criteria, business case expectations, prioritization methods, and sequencing.</li> <li>Maintain portfolio roadmaps and dependency management, and partner with IT and business leaders to align priorities to capacity, funding, and critical milestones using scenario-based planning across internal teams and external partners.</li> </ul> Governance, Decision Support, and Executive Visibility <ul> <li>Establish governance processes that enable timely decisions for technology investment, system selection, and program execution (including escalation paths and decision-ready materials).</li> <li>Support and help run the IT Steering Committee (ITSC) under the direction of the committee Chair; provide regular IT portfolio updates to committee members.</li> <li>Drive transparent reporting on schedule, risks/issues, dependencies, and delivery health across the portfolio.</li> <li>Define portfolio success measures including adoption, operational readiness, and value realization, and lead post implementation reviews to improve delivery performance and business outcomes.</li> </ul> Program Execution Excellence <ul> <li>Drive consistent project controls across the portfolio (scope, schedule, change control, stakeholder communications) and coach project managers/project leads.</li> <li>Provide delivery governance for vendor-led initiatives, ensuring accountability to plans, milestones, acceptance criteria, and risk management.</li> </ul> Regulated, Audit-Ready Delivery and PMO Enablement <ul> <li>Develop and maintain IT PMO policies, procedures, and SOPs aligned with FDA/GxP expectations; ensure project delivery practices support regulated system implementation and validation/assurance.</li> <li>Advise on IT PMO tooling and workflows (e.g., Smartsheet, ServiceNow, Box GxP/SharePoint) and drive adoption through training and change management.</li> </ul> Qualifications <ul> <li>Bachelor’s degree required; advanced degree preferred.</li> <li>A minimum of 10+ years of progressive experience in IT project/program/portfolio management and/or PMO leadership; life sciences/biotech experience strongly preferred.</li> <li>Demonstrated experience designing, implementing, and scaling PMO frameworks in growing or transforming organizations.</li> <li>Demonstrated experience leading complex enterprise system and infrastructure implementations in a high growth life sciences organization across R&amp;D and G&amp;A functions.</li> <li>PMP certification and ITIL v4 certification or equivalent credentials are a plus.</li> </ul> Knowledge and Skills <ul> <li>Strong command of project, program, and portfolio management methodologies; experience establishing governance models and executive-level reporting.</li> <li>Working knowledge of regulated environments and enterprise controls, including relevant concepts such as SOX, privacy (e.g., GDPR), and FDA 21 CFR Part 11.</li> <li>Experience supporting validation/assurance approaches (CSV/CSA) and third-party risk management (TPRM) in GxP-regulated environments.</li> <li>Strong financial and analytical skills, able to build business cases, forecast and track spend, and translate portfolio data into decision ready insights for executives.</li> <li>Proficiency with PMO tools used for portfolio planning, reporting, and governance (e.g., Smartsheet, ServiceNow, Box GxP/SharePoint, Teams/Zoom).</li> <li>Proven ability to create policies, SOPs, and training programs that drive adoption and consistent execution.</li> <li>Excellent stakeholder management, communication, and influence skills; ability to lead through ambiguity and align cross-functional teams.</li> <li>High integrity and sound judgment when handling sensitive systems, data, and business-critical initiatives.</li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="title">Washington State Pay Range</div><div class="pay-range">$199,498&mdash;$235,000 USD</div></div></div><div class="content-conclusion">E/E/O Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. E-Verify Immunome, Inc. is a participant in E-Verify. Please review the following notices: <a href="https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk" target="_blank">E-Verify Participation Poster</a> | <a href="https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e" target="_blank">Right to Work Poster (English)</a> | <a href="https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u" target="_blank">Right to Work Poster (Spanish)</a>.</div>