Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Director, Field Execution and Excellence 

Madrigal is seeking a highly collaborative, resilient, and execution-oriented leader for the role of Director, Field Execution and Excellence. 

Reporting to the Senior Director, Sales Development and Execution Excellence, this role will lead program management for Field Sales-sponsored initiatives and support the integration of cross-functional initiatives with a meaningful field-facing component. The Director will serve as a key connection point between Field Sales, other field-facing teams, and home-office partners to ensure priorities are effectively planned, coordinated, communicated, and implemented.  Broader program leadership may be assigned when specifically designated by the executive sponsor or Senior Director, Sales Development and Execution Excellence. 

The Director will anticipate field implications to then translate strategic national priorities into actionable project plans, governance, timelines, budgets, communications, and implementation plans; anticipate dependencies and execution risks; and drive accountability across teams without formal authority. This individual will partner closely with Sales leadership and cross-functional stakeholders to improve field readiness, adoption, and execution. 

Position Responsibilities 

Field Sales Program Governance 

• Lead program management for Field Sales-sponsored initiatives and maintain visibility across other priority initiatives requiring significant field-facing coordination or implementation. 

• Translate strategic direction into clear, actionable, and measurable program plans, including governance, operating cadences, stakeholder responsibilities, decision points, and escalation pathways. 

• Identify competing priorities, capacity constraints, dependencies, sequencing issues, and execution risks, providing timely recommendations to leadership. 

• Drive accountability by ensuring decisions, commitments, owners, and follow-up actions are clearly documented and completed. 

• Develop concise executive updates highlighting progress, risks, decisions required, resource implications, field feedback, and recommended actions. 

National meetings and commercial operating cadence 

• Lead project management for major national and field-facing meetings and initiatives, including Annual Regional Reviews, Plans of Action, National Sales Meetings, People Leader Meetings, Fast Start meetings, and other national or zone-level meetings.  

• Manage integrated timelines, stakeholder workstreams, content-development processes, presenter preparation, leadership reviews, communications, and post-meeting follow-through. 

• Partner with meeting-planning, administrative, Training, Marketing, and external resources to ensure that logistical execution supports the strategic objectives of each meeting.  

• Ensure that meeting outcomes are translated into clearly assigned actions, field expectations, and measurable follow-through.  

Cross-Functional Field Integration 

• Lead the execution of assigned national commercial initiatives and emerging business priorities. 

• Serve as a key connection point between Field Sales, other field-facing teams, and home-office functions to ensure field implications and implementation requirements are understood early in the planning process. 

• Coordinate roles, responsibilities, timelines, dependencies, deliverables, and decision points across participating stakeholders. 

• Partner with functional owners to support field readiness, communication, training, implementation, and adoption while preserving functional ownership of strategy, content, systems, and approvals. 

• Incorporate field perspectives into planning, identify implementation barriers, and develop change-management approaches to improve field adoption and execution. 

• Facilitate cross-functional problem solving and escalate issues requiring changes in strategy, resources, timing, scope, or senior-leadership alignment. 

• Ensure that work requiring Legal, Medical, Regulatory, or Compliance review is routed through the appropriate approval process before dissemination.  

Process improvement and operational effectiveness 

• Identify opportunities to simplify, standardize, automate, or eliminate inefficient field-facing processes.  

• Lead or support process-improvement initiatives involving field platforms, communications, reporting workflows, meeting processes, and cross-functional coordination. 

• Partner with Information Technology, Commercial Operations, Analytics, and system owners on initiatives involving Veeva and other field-facing technology.  

• Develop repeatable processes, templates, tools, and governance mechanisms that improve efficiency, visibility, and accountability.  

• Partner with Executive Sales Directors, Regional Sales Directors, Field Development Managers, and other field leaders to identify implementation barriers and improve field adoption.  

• Provide temporary leadership coverage for open Regional Sales Director roles, as needed and based on business priorities, field circumstances, and available capacity, to support continuity of leadership and field execution. 

Budget and vendor management 

• Develop and manage budgets for assigned programs, including forecasting, expenditure tracking, cost controls, and identification of financial risks 

• Coordinate with Finance, Procurement, Legal, and functional stakeholders on external vendor engagement and contracting.  

• Manage vendor performance for assigned initiatives, ensuring adherence to scope, timelines, quality standards, and financial commitments.  

• Develop business cases and resource recommendations when additional investment or support is required.  

Qualifications and Skills 

Required qualifications 

• At least 2+ years of first-line pharmaceutical/biotech field sales leadership with a strong understanding of operational realities of leading a sales team, anticipating field implications, influencing sales leaders and cross functional stakeholders, and translating national priorities into practical, executable field plans. 

• Bachelor's degree  

• 8+ years of relevant commercial experience  

• Experience coaching/developing field teams and understanding field leadership  

• Experience leading complex national cross-functional programs  

• Strong understanding of pharmaceutical commercialization  

• Ability to influence without authority and work with executives  

• Strong program/project management capabilities and enterprise commercial acumen 

• Budget/vendor management experience  

• Strong communication and facilitation skills  

• Ability to operate independently and collaboratively in a fast-paced environment  

• Up to 50% travel-flexible for additional travel during periods of increased business need 

Preferred qualifications 

• Advanced degree in business, healthcare, operations, or a related field.  

• Formal program- or project-management certification.  

• Experience supporting national sales meetings, business reviews, launches, field communications, or commercial transformation initiatives.  

• Prior experience in both field-facing and headquarters-based commercial roles.  

• Demonstrated proficiency with AI tools and an ability to apply them thoughtfully and responsibly to improve planning, communication, analysis, and operational efficiency. 

• Experience with Veeva or comparable pharmaceutical commercial platforms.  

• Experience leading organizational change or field-adoption initiatives.  

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.