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Director, Commercial Data & Analytics

About Krystal Bio: At Krystal Biotech, we bring together the brightest and most eager minds to relentlessly pursue the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs.

Founded in 2016, Krystal is distinguished in three powerful ways: science and technology using our patented gene therapy platform, innovative manufacturing supported by our commercial scale facilities, and a unique commercialization model that focuses on the patient’s end-to-end experience.

Krystal received U.S. FDA approval for the first and only redosable gene therapy treatment, VYJUVEK®, for the treatment of Dystrophic Epidermolysis Bullosa (DEB). Krystal continues to leverage our proprietary platform to rapidly advance a robust pipeline of investigational genetic medicines in respiratory, oncology, dermatology, and ophthalmology.

Krystal is headquartered in Pittsburgh, PA, which is home to our two state-of-the-art CGMP manufacturing facilities with teams around the world and satellite offices in Switzerland, Germany, and Japan. We are a company built and run by people who care, are fearless in the face of a challenge, love the work they do, and practice the highest level of scientific integrity. As we grow, we are seeking team members that embody these values.

Job Description Summary

Krystal Biotech, Inc. is seeking a strategic and hands-on Director of Commercial Data & Analytics to lead commercial analytics strategy in support of our rare disease portfolio. This role will serve as the central driver of commercial data insights, partnering closely with Commercial Leadership, Finance, Patient Services, Market Access, and other cross-functional stakeholders to translate business strategy into measurable performance metrics and actionable insights.

The ideal candidate will bring deep rare disease commercial experience, strong business acumen, and the ability to synthesize complex datasets into cohesive, decision-driving narratives. This individual will play a critical role in monitoring execution metrics, evaluating commercial effectiveness, and ensuring leadership has clear visibility into performance trends and strategic implications.

Primary Responsibilities

Serve as the commercial analytics lead, translating business strategy into measurable indicators and performance dashboards across Sales, Market Access, and Patient Services.
Compile, analyze, and synthesize diverse data sources to generate cohesive, executive-level insights and narratives.
Monitor execution metrics and proactively identify trends, risks, and opportunities across the commercial organization.
Partner cross-functionally with Commercial Leadership, Finance, Market Access, Patient Services, and other key stakeholders to ensure alignment between strategy, performance measurement, and execution.
Collaborate with Finance to support forecasting processes by providing commercial insights and contextual interpretation of performance drivers; while not directly owning forecasting, ensure alignment between field execution and forecast assumptions.
Develop and refine commercial reporting frameworks to improve clarity, efficiency, and strategic decision-making.
Analyze patient services and patient journey data to provide insights that optimize access, pull-through, and overall patient experience.
Establish data governance standards and best practices to ensure data integrity and consistency across commercial functions.
Support launch readiness and post-launch performance tracking for rare disease products.
Present insights and strategic recommendations to senior leadership in a clear and compelling manner.
Identify opportunities to streamline analytics processes while maximizing impact within a lean operating structure.
Perform other duties as assigned.

Requirements and Preferred Qualifications

Bachelor’s degree required; advanced degree (MBA, MS, or similar) highly preferred.
10+ years of progressive experience in commercial analytics, commercial operations, or business analytics within biotechnology or pharmaceutical organizations.
Rare disease commercial experience required.
Demonstrated experience working cross-functionally in a high-growth biotech or specialty pharmaceutical environment.
Experience supporting commercial launch activities and post-launch optimization phase, strongly preferred.
Experience working closely with Finance on forecasting inputs and performance analytics preferred.
Experience analyzing patient services data and patient access metrics is a plus.
Adaptable; capable of managing priorities in a dynamic and rapidly changing business environment.

Krystal Biotech, Inc. is an Equal Employment Opportunity and Affirmative Action Employers. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, or disability status. Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers. Krystal Biotech, Inc. does not accept unsolicited headhunter and agency resumes. Krystal Biotech, Inc. will not pay fees to any third-party agency or company that does not have a signed agreement with Krystal Biotech, Inc.

Director, Commercial Data & Analytics

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