Director, Clinical Research-Program Executive-Oncology

THE OPPORTUNITY

Vir Biotechnology is seeking an experienced Senior Director, Clinical Research Oncology Program Executive (PE) to serve as the development team leader and single point of accountability for one or more oncology development programs. This highly visible leadership role sits at the intersection of clinical development, program strategy, and corporate execution.

The Oncology PE will be responsible for defining and driving the overall development strategy, ensuring alignment across functions, and leading cross-functional teams to achieve key development milestones. The individual will partner closely with executive leadership to shape program direction, evaluate risks and opportunities, prioritize investments, and ensure successful execution of Vir Bio’s oncology portfolio.

You will be successful in this role if you bring deep oncology drug development experience and enjoy translating complex scientific and clinical insights into clear development strategies. You are comfortable working across functions, influencing decisions at all levels of the organization, and helping teams navigate key development milestones and strategic decisions.

This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office.

WHAT YOU'LL DO

• Serve as the cross-functional leader and single point of accountability for one or more oncology development programs
• Define and drive overall program vision, clinical development strategy, key milestones, and integrated development plans
• Lead cross-functional program teams to align on objectives, priorities, timelines, resource needs, and risk mitigation strategies
• Partner with executive leadership and governance committees to support strategic decision-making and portfolio prioritization
• Ensure programs are appropriately resourced and provide oversight and input on major budget and investment decisions
• Leverage deep oncology and clinical development expertise to guide development strategy, clinical trial planning, data interpretation, and key program decisions
• Represent programs at senior leadership meetings, governance reviews, alliance meetings, regulatory interactions, and other external forums
• Mentor and develop team members while helping strengthen program leadership capabilities across the organization
• Own the integrated development plan and target product profile, including stage gates, evidence requirements, and clear go/no-go recommendations.
• Chair the development team, establish decision rights and accountabilities, resolve issues promptly, and escalate material tradeoffs with a recommendation.
• Ensure fit-for-purpose translational medicine, clinical pharmacology, biomarker, companion-diagnostic, and patient-selection strategies from first-in-human development through registration.
• Guide indication prioritization, sequencing, combination strategy, and lifecycle planning based on scientific rationale, unmet need, speed to interpretable data, competitive intensity, regulatory feasibility, and commercial opportunity.
• Define data-readout and evidence-generation plans that support rapid learning, early de-risking, and disciplined investment.
• Partner with Regulatory Affairs on global strategy, health-authority engagement, dose optimization, and expedited-development opportunities supported by data.
• Coordinate Clinical Operations, Biometrics, Safety, CMC/Technical Operations, Medical Affairs, and Commercial to ensure integrated execution, inspection readiness, and a coherent program narrative.
• Maintain integrated financial, timeline, resource, dependency, and risk scenarios; recommend corrective action as assumptions or data change.
• Engage investigators, key opinion leaders, collaborators, and potential partners, incorporating external insights into program strategy.
• Incorporate patient burden, feasibility, diversity, access, and clinically meaningful outcomes into program and study decisions.

WHO YOU ARE AND WHAT YOU BRING

• MD or PhD; board certification in Oncology, Hematology/Oncology, or a related specialty preferred
• 15+ years of biotechnology or pharmaceutical industry experience with substantial experience in oncology drug development
• Demonstrated success leading cross-functional development programs in a matrix environment
• Deep understanding of oncology clinical development, including experience across early and late-stage development
• Experience serving as a Medical Director, Clinical Research Physician, Program Team Leader, or comparable development leadership role
• Strong strategic thinking and ability to integrate scientific, clinical, regulatory, operational, and commercial considerations into development plans
• Exceptional executive communication, facilitation, negotiation, and conflict-resolution skills.
• Experience presenting to executive leadership teams, governance committees, boards, and external stakeholders
• Track record of advancing an oncology program through a major value inflection point, such as first-in-human entry, proof of concept, dose selection, pivotal initiation, regulatory submission, or approval.
• Ability to make decisions under uncertainty and communicate the rationale, assumptions, alternatives, and consequences clearly.
• High integrity, sound judgment, enterprise mindset, and accountability for strategy and execution.
• Ability to travel domestically and internationally as needed.