Clinical Contract Manager

Company Overview 

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. 

Summary

We are seeking a Clinical Contract Manager (CCM) to lead the end-to-end clinical site contracting process in support of our growing clinical portfolio. This role will serve as the primary sponsor contact for Contract Research Organization (CRO) partners and internal stakeholders across Clinical, Legal, Finance, and Compliance. 

In a fast-paced, small biotech environment, the CCM will drive the development, negotiation, execution, and maintenance of Clinical Trial Agreements (CTAs), ensuring alignment with trial timelines, budget, and regulatory requirements. This individual will play a key role in enabling timely site activation, CTA maintenance as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of CTAs with applicable regulations and internal standards. 

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your Role 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

 

What You Bring 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

 #LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status